Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
bacterial toxin
|
| gptkbp:alternativeName |
C. difficile toxin B
|
| gptkbp:cause |
gptkb:pseudomembranous_colitis
diarrhea colonic inflammation |
| gptkbp:discoveredBy |
John G. Bartlett
|
| gptkbp:effect |
induces cell death
disrupts actin cytoskeleton |
| gptkbp:encodedBy |
tcdB gene
|
| gptkbp:firstDescribed |
1980s
|
| gptkbp:foundIn |
Clostridioides difficile strains
|
| https://www.w3.org/2000/01/rdf-schema#label |
Toxin B
|
| gptkbp:inhibitedBy |
neutralizing antibodies
|
| gptkbp:mechanismOfAction |
glucosylates Rho GTPases
|
| gptkbp:molecularWeight |
~270 kDa
|
| gptkbp:producedBy |
gptkb:Clostridioides_difficile
|
| gptkbp:relatedTo |
Toxin A (C. difficile toxin A)
|
| gptkbp:role |
major virulence factor in C. difficile infection
|
| gptkbp:structureType |
large clostridial cytotoxin
|
| gptkbp:targetCellType |
intestinal epithelial cells
|
| gptkbp:usedIn |
diagnosis of C. difficile infection
|
| gptkbp:bfsParent |
gptkb:Clostridioides_difficile
|
| gptkbp:bfsLayer |
6
|