|
gptkbp:instanceOf
|
gptkb:drug
beta blocker
antiarrhythmic agent
|
|
gptkbp:ATCCode
|
C07AA07
|
|
gptkbp:bioavailability
|
90-100%
|
|
gptkbp:CASNumber
|
3930-20-9
|
|
gptkbp:category
|
beta blocker
antiarrhythmic agent
|
|
gptkbp:chemicalFormula
|
contains sulfonamide group
|
|
gptkbp:contraindication
|
gptkb:congenital_long_QT_syndrome
asthma
severe bradycardia
second or third degree heart block
|
|
gptkbp:discoveredBy
|
gptkb:ICI_Pharmaceuticals
|
|
gptkbp:eliminationHalfLife
|
12 hours
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:hasMolecularFormula
|
C12H20N2O3S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sotalol
|
|
gptkbp:introducedIn
|
1970s
|
|
gptkbp:isomerOf
|
racemic mixture
|
|
gptkbp:KEGGID
|
D00441
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
non-selective beta-adrenergic receptor blocker
class III antiarrhythmic (potassium channel blocker)
|
|
gptkbp:MedlinePlusID
|
a693008
|
|
gptkbp:metabolism
|
not metabolized
|
|
gptkbp:pregnancyCategory
|
gptkb:C_(UK)
B (US)
B3 (Australia)
|
|
gptkbp:proteinBinding
|
0%
|
|
gptkbp:PubChem_CID
|
5061
5253
CHEMBL1537
DB00489
|
|
gptkbp:riskOfQTProlongation
|
yes
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
gptkb:torsades_de_pointes
dizziness
fatigue
bradycardia
|
|
gptkbp:synonym
|
Betapace
Sotacor
|
|
gptkbp:UNII
|
A0V1W1OEC6
|
|
gptkbp:usedFor
|
gptkb:atrial_fibrillation
ventricular arrhythmias
atrial flutter
treating abnormal heart rhythms
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Atrial_Flutter
|
|
gptkbp:bfsLayer
|
7
|