Sildenafil

GPTKB entity

Statements (63)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkb:drug
gptkbp:approvalYear 1998
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode gptkb:G04BE03
gptkbp:availableOn gptkb:tablet
oral suspension
injectable
gptkbp:bioavailability 40%
gptkbp:brand gptkb:Revatio
gptkb:Viagra
gptkbp:CASNumber 139755-83-2
gptkbp:category vasodilator
erectile dysfunction drug
gptkbp:chemicalFormula C22H30N6O4S
gptkbp:contraindication nitrate medication
severe cardiovascular disorders
gptkbp:developedBy gptkb:Pfizer
gptkbp:discoveredBy gptkb:Pfizer
gptkbp:discoveredIn 1989
gptkbp:drugClass phosphodiesterase inhibitor
gptkbp:eliminationHalfLife 3-5 hours
gptkbp:excretion urine
feces
gptkbp:firstSynthesized 1989
https://www.w3.org/2000/01/rdf-schema#label Sildenafil
gptkbp:interactsWith CYP3A4 inhibitors
nitrates
alpha-blockers
CYP3A4 inducers
gptkbp:IUPACName gptkb:1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine
gptkbp:KEGGID D08514
gptkbp:legalStatus prescription only
gptkbp:marketedAs gptkb:Pfizer
gptkbp:mechanismOfAction PDE5 inhibitor
gptkbp:MedlinePlusID a699015
gptkbp:metabolism liver
gptkbp:molecularWeight 474.6 g/mol
gptkbp:patentExpired 2013
gptkbp:pregnancyCategory B (US)
B1
gptkbp:proteinBinding 96%
gptkbp:PubChem_CID 5212
CHEMBL192
DB00203
gptkbp:riskFactor priapism
sudden hearing loss
sudden vision loss
gptkbp:routeOfAdministration oral
intravenous
gptkbp:sideEffect headache
nasal congestion
dyspepsia
flushing
visual disturbances
gptkbp:UNII 3M7OB98Y7H
gptkbp:usedFor erectile dysfunction
pulmonary arterial hypertension
gptkbp:bfsParent gptkb:148553-50-8
gptkb:169590-42-5
gptkb:119302-91-9
gptkb:136817-59-9
gptkbp:bfsLayer 7