Alex Karev as chief of surgery
Amelia Shepherd's personal growth
Andrew DeLuca's relationship with Meredith
Catherine Fox's cancer diagnosis
Fire at the hospital
Jackson Avery and Maggie Pierce's relationship
Jackson Avery's disappearance
Jo Karev's depression
Jo Karev's mental health
Jo Karev's search for her birth mother
Levi Schmitt's coming out
Link and Amelia's relationship
Meredith Grey's insurance fraud
Meredith Grey's love life
Nico Kim and Levi Schmitt's relationship
Owen Hunt's family drama
Richard Webber's struggles
Teddy Altman and Owen Hunt's baby
Teddy Altman's pregnancy