|
gptkbp:instanceOf
|
gptkb:drug
beta blocker
|
|
gptkbp:approvedBy
|
gptkb:FDA
1964
|
|
gptkbp:ATCCode
|
C07AA05
|
|
gptkbp:bioavailability
|
25% (oral)
|
|
gptkbp:brand
|
gptkb:Inderal
gptkb:InnoPran_XL
gptkb:Hemangeol
|
|
gptkbp:CASNumber
|
525-66-6
|
|
gptkbp:chemicalFormula
|
C16H21NO2
|
|
gptkbp:contraindication
|
asthma
heart block
severe bradycardia
|
|
gptkbp:discoveredBy
|
gptkb:James_W._Black
|
|
gptkbp:eliminationHalfLife
|
3-6 hours
|
|
gptkbp:excretion
|
urine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Propranolol
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
non-selective beta-adrenergic receptor antagonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
90%
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
dizziness
fatigue
sleep disturbances
hypotension
bradycardia
|
|
gptkbp:usedFor
|
gptkb:thyrotoxicosis
gptkb:arrhythmia
gptkb:essential_tremor
anxiety
hypertension
angina
migraine prevention
myocardial infarction prevention
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Anti-Anxiety_Agents
|
|
gptkbp:bfsLayer
|
7
|