|
gptkbp:instanceOf
|
gptkb:drug
analgesic
|
|
gptkbp:abusePotential
|
yes
|
|
gptkbp:antidote
|
supportive care
|
|
gptkbp:approvedInUS
|
1989
|
|
gptkbp:ATCCode
|
N01AX10
|
|
gptkbp:boilingPoint
|
256°C
|
|
gptkbp:brand
|
gptkb:Diprivan
|
|
gptkbp:CASNumber
|
2078-54-8
|
|
gptkbp:chemicalFormula
|
C12H18O
|
|
gptkbp:color
|
milky white emulsion
|
|
gptkbp:contraindication
|
allergy to egg or soy
|
|
gptkbp:discoveredBy
|
gptkb:ICI_Pharmaceuticals
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:eliminationHalfLife
|
1.5–31 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Propofol
|
|
gptkbp:IUPACName
|
gptkb:2,6-diisopropylphenol
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
positive allosteric modulator of GABAA receptor
|
|
gptkbp:meltingPoint
|
19°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
178.27 g/mol
|
|
gptkbp:notableUser
|
gptkb:Michael_Jackson_(overdose_death)
|
|
gptkbp:origin
|
synthetic
|
|
gptkbp:overdoseSymptoms
|
cardiac and respiratory depression
|
|
gptkbp:pregnancyCategory
|
B
|
|
gptkbp:PubChem_CID
|
4943
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:sideEffect
|
gptkb:propofol_infusion_syndrome
hypotension
respiratory depression
pain at injection site
bradycardia
|
|
gptkbp:solubility
|
insoluble in water
soluble in lipids
|
|
gptkbp:storage
|
protect from light
|
|
gptkbp:UNII
|
0J9J93A0HK
|
|
gptkbp:usedFor
|
procedural sedation
induction of anesthesia
maintenance of anesthesia
sedation for mechanically ventilated adults
|
|
gptkbp:usedIn
|
operating rooms
intensive care units
emergency departments
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:Hospira
|
|
gptkbp:bfsLayer
|
5
|