Statements (97)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:pharmaceuticals
gptkb:Bastiladon |
| gptkbp:administered_by |
hospital settings
oral medication post-surgical infections |
| gptkbp:approves |
gptkb:Germany
|
| gptkbp:associated_with |
gptkb:pharmaceuticals
gptkb:Bayer_AG therapeutic drug monitoring infectious disease treatment infectious disease control clinical pharmacology antibiotic stewardship public health advancements medical ethics debates antimicrobial therapy antibiotic resistance discussions drug development history |
| gptkbp:chemical_formula |
C12 H13 N3 O2 S
|
| gptkbp:class |
sulfonamides
|
| gptkbp:clinical_trial |
conducted in the 1930s
|
| gptkbp:composed_by |
gptkb:chemical_compound
|
| gptkbp:cultural_impact |
featured in medical history discussions
|
| gptkbp:developed_by |
gptkb:sulfanilamide
|
| gptkbp:discovered_by |
gptkb:Gerhard_Domagk
|
| gptkbp:discovery |
led to the development of other antibiotics
|
| gptkbp:discovery_year |
gptkb:1932
|
| gptkbp:dissolved |
poorly soluble in water
|
| gptkbp:features_works_by |
inhibiting bacterial growth
|
| gptkbp:field_of_study |
gptkb:Medicine
chemistry pharmacology |
| gptkbp:first_appearance |
sulfa drug used clinically
|
| gptkbp:first_introduced |
gptkb:1932
gptkb:humans |
| gptkbp:has_impact_on |
modern pharmacology
|
| gptkbp:historical_significance |
first synthetic antibiotic
|
| https://www.w3.org/2000/01/rdf-schema#label |
Prontosil
|
| gptkbp:impact_on_medicine |
revolutionized treatment of infections
|
| gptkbp:influenced_by |
Alexander Fleming's penicillin
earlier antiseptics |
| gptkbp:invention |
patented
|
| gptkbp:is_a |
prodrug
|
| gptkbp:is_associated_with |
gptkb:Domagk's_Nobel_Prize
bacterial resistance |
| gptkbp:is_available_in |
tablet form
|
| gptkbp:is_considered |
historically significant
a breakthrough in medicine a milestone in antibiotic development a precursor to penicillin the first antibiotic discovered |
| gptkbp:is_effective_against |
fungal infections
viral infections chronic infections parasitic infections Streptococcus infections effective against streptococcal infections mycobacterial infections |
| gptkbp:is_metabolized_to |
sulfanilamide in the body
|
| gptkbp:is_part_of |
medical history
antimicrobial therapy sulfonamide antibiotics antibiotic class antibiotic history |
| gptkbp:is_studied_for |
its mechanism of action
|
| gptkbp:is_used_for |
bacterial infections
|
| gptkbp:is_used_in |
gptkb:animals
combination therapy preventive treatment current medical practice treatment of respiratory infections treatment of sepsis treatment of skin infections treatment of urinary tract infections |
| gptkbp:legacy |
paved the way for modern antibiotics
|
| gptkbp:market_position |
1950s
widely used during World War II |
| gptkbp:marketed_as |
gptkb:Bayer
|
| gptkbp:mechanism_of_action |
inhibits folic acid synthesis
|
| gptkbp:metabolism |
sulfanilamide in the body
|
| gptkbp:related_to |
gptkb:sulfanilamide
|
| gptkbp:replaced_by |
more effective antibiotics
|
| gptkbp:side_effect |
allergic reactions
|
| gptkbp:suitable_for |
pregnant women
patients with liver disease children under 2 patients with allergies to sulfa drugs patients with kidney issues |
| gptkbp:treatment |
gptkb:pneumonia
meningitis sepsis urinary tract infections wound infections |
| gptkbp:type |
gptkb:pharmaceuticals
|
| gptkbp:used_for |
bacterial infections
|
| gptkbp:bfsParent |
gptkb:Gerhard_Domagk
|
| gptkbp:bfsLayer |
6
|