Primary Sclerosing Cholangitis

URI: https://gptkb.org/entity/Primary_Sclerosing_Cholangitis
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:disease
gptkbp:abbreviation gptkb:PSC
gptkbp:affects liver
bile ducts
gptkbp:associatedWith gptkb:inflammatory_bowel_disease
ulcerative colitis
gptkbp:autoimmuneComponent yes
gptkbp:cause liver failure
cholangiocarcinoma
liver cirrhosis
inflammation of bile ducts
scarring of bile ducts
gptkbp:complication gptkb:fat-soluble_vitamin_deficiency
gptkb:bone
portal hypertension
bile duct strictures
gptkbp:diagnosedBy liver biopsy
MRI
blood tests
cholangiography
gptkbp:etiology gptkb:unknown
gptkbp:firstDescribed 1867
gptkbp:gender more common in males
gptkbp:ICD-10_code K83.0
gptkbp:medianSurvivalAfterDiagnosis 10-20 years
gptkbp:MeSH_ID D015215
gptkbp:mortalityRate increased
gptkbp:notableFor autoimmune hepatitis
colorectal cancer (in patients with IBD)
gptkbp:OMIM 613806
gptkbp:onset adulthood
gptkbp:prevalence rare
gptkbp:prognosis variable
gptkbp:progression chronic
gptkbp:riskFactor male sex
northern European descent
gptkbp:symptom abdominal pain
fatigue
jaundice
pruritus
gptkbp:treatment gptkb:ursodeoxycholic_acid
liver transplant
symptomatic management
endoscopic therapy
gptkbp:bfsParent gptkb:PSC
gptkbp:bfsLayer 6
https://www.w3.org/2000/01/rdf-schema#label Primary Sclerosing Cholangitis