Primary Sclerosing Cholangitis
GPTKB entity
Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
|
| gptkbp:abbreviation |
gptkb:PSC
|
| gptkbp:affects |
liver
bile ducts |
| gptkbp:associatedWith |
ulcerative colitis
inflammatory bowel disease |
| gptkbp:autoimmuneComponent |
yes
|
| gptkbp:cause |
liver failure
cholangiocarcinoma liver cirrhosis inflammation of bile ducts scarring of bile ducts |
| gptkbp:complication |
gptkb:fat-soluble_vitamin_deficiency
gptkb:bone portal hypertension bile duct strictures |
| gptkbp:diagnosedBy |
liver biopsy
MRI blood tests cholangiography |
| gptkbp:etiology |
unknown
|
| gptkbp:firstDescribed |
1867
|
| gptkbp:gender |
more common in males
|
| https://www.w3.org/2000/01/rdf-schema#label |
Primary Sclerosing Cholangitis
|
| gptkbp:ICD-10_code |
K83.0
|
| gptkbp:medianSurvivalAfterDiagnosis |
10-20 years
|
| gptkbp:MeSH_ID |
D015215
|
| gptkbp:mortalityRate |
increased
|
| gptkbp:notableFor |
autoimmune hepatitis
colorectal cancer (in patients with IBD) |
| gptkbp:OMIM |
613806
|
| gptkbp:onset |
adulthood
|
| gptkbp:prevalence |
rare
|
| gptkbp:prognosis |
variable
|
| gptkbp:progression |
chronic
|
| gptkbp:riskFactor |
male sex
northern European descent |
| gptkbp:symptom |
abdominal pain
fatigue jaundice pruritus |
| gptkbp:treatment |
gptkb:ursodeoxycholic_acid
liver transplant symptomatic management endoscopic therapy |
| gptkbp:bfsParent |
gptkb:PSC
gptkb:PSS |
| gptkbp:bfsLayer |
6
|