Peramivir

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instance_of gptkb:immunotherapy
gptkbp:activities effective against influenza A and B viruses
gptkbp:administered_by intravenous injection
gptkbp:approves gptkb:2014
gptkb:FDA
gptkbp:availability available by prescription only
gptkbp:brand gptkb:Rapivab
gptkbp:casnumber 209216-23-9
gptkbp:chemical_formula C16 H20 N2 O4
gptkbp:clinical_trial completed
Phase III trials completed
gptkbp:clinical_use treatment of influenza in adults and children
gptkbp:contraindication hypersensitivity to peramivir
gptkbp:developed_by gptkb:Bio_Cryst_Pharmaceuticals
gptkbp:drug_interactions minimal drug interactions
gptkbp:duration single dose treatment
gptkbp:effective_date December 2014
gptkbp:excretion primarily through urine
gptkbp:formulation lyophilized powder for reconstitution
https://www.w3.org/2000/01/rdf-schema#label Peramivir
gptkbp:indication acute uncomplicated influenza
gptkbp:is_effective_against demonstrated efficacy in clinical trials
gptkbp:marketed_as gptkb:Rapivab
gptkbp:mechanism_of_action neuraminidase inhibitor
gptkbp:metabolism not extensively metabolized
gptkbp:notable_work shown to reduce duration of symptoms
gptkbp:packaging single-use vial
gptkbp:patient_education patients advised to report side effects
gptkbp:patient_population adults and pediatric patients
gptkbp:pharmacokinetics inhibits viral replication
elimination half-life of approximately 20 hours
gptkbp:price varies by pharmacy
gptkbp:production_status approved for use in the United States
gptkbp:provides_guidance_on recommended for high-risk patients
CDC recommends use in certain cases
gptkbp:research_institutes studied in multiple clinical research centers
gptkbp:research_status ongoing studies for efficacy in other viral infections
gptkbp:route_of_administration IV
gptkbp:safety_features generally well tolerated
gptkbp:safety_measures monitored post-marketing
gptkbp:service_frequency once daily for 1 day
gptkbp:side_effect headache
nausea
diarrhea
allergic reactions possible
elevated liver enzymes
gptkbp:storage store at room temperature
gptkbp:supply_chain manufactured under strict regulations
gptkbp:target_audience patients with influenza
gptkbp:used_for treatment of influenza
gptkbp:bfsParent gptkb:Daiichi_Sankyo
gptkbp:bfsLayer 5