Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
involved in cell cycle regulation
studied in the context of cancer research |
| gptkbp:associated_with |
ciliary assembly
|
| gptkbp:binding_partners |
binds to various signaling molecules
|
| gptkbp:breeding_range |
located on chromosome 2
|
| gptkbp:cellular_role |
involved in cellular motility
|
| gptkbp:clinical_trial |
important in biomedical research.
investigated for therapeutic targets potential biomarker for certain diseases |
| gptkbp:collaborations |
collaborated on studies with various institutions
|
| gptkbp:discovery_year |
discovered in 2000
|
| gptkbp:diseases |
associated with ciliopathies
linked to polycystic kidney disease |
| gptkbp:field_of_study |
cell biology
|
| gptkbp:function |
involved in the regulation of cilia
|
| gptkbp:function_in_development |
critical for proper organ development
|
| gptkbp:functional_assays |
assayed for ciliary function
|
| gptkbp:functional_domains |
contains several functional domains
|
| gptkbp:gene_expression |
regulated during cell differentiation
|
| gptkbp:genetic_studies |
highly conserved across species
mutations can lead to developmental disorders studied in genetic linkage analysis |
| https://www.w3.org/2000/01/rdf-schema#label |
NIRC2
|
| gptkbp:interacts_with |
interacts with IFT proteins
other ciliary proteins |
| gptkbp:is_expressed_in |
expressed in various tissues
expressed during embryonic development |
| gptkbp:knockout_effects |
knockout leads to ciliary defects
|
| gptkbp:localization |
localized to the ciliary axoneme
|
| gptkbp:location |
located in the cytoplasm
|
| gptkbp:model_organisms |
studied in zebrafish models
|
| gptkbp:notable_work |
findings suggest role in sensory perception
|
| gptkbp:nutritional_value |
has a complex tertiary structure
interacts with dynein motor proteins interacts with other cytoskeletal proteins localized to the ciliary membrane part of the intraflagellar transport family |
| gptkbp:orthologs |
has orthologs in multiple species
|
| gptkbp:pathological_role |
implicated in developmental disorders
|
| gptkbp:pathway |
involved in the Hedgehog signaling pathway
|
| gptkbp:promoter |
gptkb:NIRC2_gene
|
| gptkbp:protein_family_classification |
classified under ciliary proteins
|
| gptkbp:protein_modification |
subject to post-translational modifications
|
| gptkbp:protein_type |
ciliary protein
|
| gptkbp:regulatory_compliance |
regulated by transcription factors
|
| gptkbp:research |
studied using CRISPR technology
|
| gptkbp:research_importance |
important for understanding ciliary function
|
| gptkbp:role |
plays a role in cell signaling
plays a role in signal transduction |
| gptkbp:subcellular_location |
found in the basal body of cilia
|
| gptkbp:weight |
approximately 100 k Da
|
| gptkbp:bfsParent |
gptkb:NASA_Infrared_Telescope_Facility
|
| gptkbp:bfsLayer |
7
|