Mycobacterium tuberculosis complex
GPTKB entity
Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:research_center
|
| gptkbp:affects |
gptkb:humans
|
| gptkbp:antigenic_variation |
limited antigenic variation
|
| gptkbp:cause |
tuberculosis
|
| gptkbp:controls |
directly observed therapy
|
| gptkbp:culture_medium |
gptkb:Lowenstein-Jensen_medium
|
| gptkbp:diagnosis |
chest X-ray
tuberculin skin test interferon-gamma release assays |
| gptkbp:discovery |
gptkb:Robert_Koch
|
| gptkbp:diseases |
extrapulmonary tuberculosis
intracellular pathogen latent tuberculosis infection |
| gptkbp:duration |
6 to 9 months
|
| gptkbp:epidemiology |
public health concern
|
| gptkbp:first_described_by |
1882
|
| gptkbp:genetic_diversity |
clonal expansion
high genetic variability |
| gptkbp:geographic_distribution |
worldwide
|
| gptkbp:global_burden |
millions of cases annually
significant mortality rate |
| gptkbp:has_features |
positive
|
| gptkbp:hosts |
gptkb:humans
|
| https://www.w3.org/2000/01/rdf-schema#label |
Mycobacterium tuberculosis complex
|
| gptkbp:includes |
gptkb:Mycobacterium_africanum
gptkb:Mycobacterium_bovis gptkb:Mycobacterium_tuberculosis Mycobacterium canettii Mycobacterium microti |
| gptkbp:is_monitored_by |
mandatory reporting in many countries
|
| gptkbp:is_vulnerable_to |
limited in adults
approximately 70% in children |
| gptkbp:prevention |
BCG vaccine
|
| gptkbp:provides_guidance_on |
combination therapy
first-line drugs second-line drugs |
| gptkbp:public_health_strategy |
education and awareness
contact tracing screening programs |
| gptkbp:research_focus |
diagnostic tests
vaccine development understanding resistance mechanisms new antibiotics |
| gptkbp:risk_factor |
gptkb:diabetes
malnutrition smoking immunosuppression HIV infection |
| gptkbp:seed_dispersal |
approximately 4.4 million base pairs
|
| gptkbp:symptoms |
weight loss
fever night sweats chronic cough |
| gptkbp:transmission |
airborne droplets
|
| gptkbp:treatment |
treatment adherence
antibiotics drug resistance cure rate with proper treatment relapse possible after treatment |
| gptkbp:virulence_factor |
mycolic acids
cord factor |
| gptkbp:water_requirement |
aerobic
|
| gptkbp:water_resistance |
multi-drug resistant tuberculosis
|