Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
Genetic Phenomenon
|
| gptkbp:abbreviation |
gptkb:MSI
|
| gptkbp:affects |
Microsatellites
|
| gptkbp:associatedWith |
gptkb:MLH1
gptkb:MSH2 gptkb:MSH6 gptkb:PMS2 Colorectal Cancer Gastric Cancer DNA Mismatch Repair Deficiency Endometrial Cancer |
| gptkbp:cause |
Altered Microsatellite Lengths
|
| gptkbp:class |
MSI-High
MSI-Low Microsatellite Stable |
| gptkbp:detects |
PCR
Immunohistochemistry Next-Generation Sequencing Blood Samples Cell-Free DNA Tumor Tissue |
| gptkbp:firstDescribed |
1993
|
| gptkbp:frequency |
Colorectal Tumors
Endometrial Tumors Gastric Tumors |
| gptkbp:hasBiomarker |
Immunotherapy Response
|
| https://www.w3.org/2000/01/rdf-schema#label |
Microsatellite Instability
|
| gptkbp:impact |
gptkb:Tumor_Mutational_Burden
Cancer Prognosis Therapeutic Decisions |
| gptkbp:importantFor |
Personalized Medicine
Cancer Screening Familial Cancer Risk Assessment |
| gptkbp:influenced |
Response to Nivolumab
Response to PD-1 Inhibitors Response to Pembrolizumab |
| gptkbp:relatedTo |
Hereditary Nonpolyposis Colorectal Cancer
Hypermutator Phenotype Lynch Syndrome Tumor Immunogenicity |
| gptkbp:result |
Defective DNA Mismatch Repair Genes
Genetic Hypermutability |
| gptkbp:studiedIn |
Genetics
Oncology Molecular Pathology |
| gptkbp:usedIn |
Cancer Diagnosis
Cancer Prognosis Cancer Treatment Selection |
| gptkbp:bfsParent |
gptkb:MSIN
|
| gptkbp:bfsLayer |
7
|