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gptkbp:instanceOf
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genetic disorder
endocrine neoplasia syndrome
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gptkbp:alsoKnownAs
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gptkb:Multiple_Endocrine_Neoplasia_type_1
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gptkbp:associatedWith
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gptkb:gastrinoma
gptkb:insulinoma
gptkb:carcinoid_tumors
lipomas
hyperparathyroidism
prolactinoma
adrenocortical tumors
angiofibromas
collagenomas
non-functioning pituitary adenoma
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gptkbp:diagnosedBy
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genetic testing
biochemical testing
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gptkbp:feature
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tumors of anterior pituitary gland
tumors of pancreatic islet cells
tumors of parathyroid glands
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gptkbp:firstDescribed
|
1954
Paul Wermer
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gptkbp:geneProduct
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menin
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|
https://www.w3.org/2000/01/rdf-schema#label
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MEN1 syndrome
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gptkbp:inheritance
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autosomal dominant
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gptkbp:inheritanceRiskToOffspring
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50%
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gptkbp:locatedOnChromosome
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gptkb:chromosome_11q13
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gptkbp:mutationAssociatedWith
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gptkb:MEN1_gene
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gptkbp:OMIM
|
131100
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gptkbp:prevalence
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1 in 30,000
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gptkbp:riskOfMalignancy
|
increased
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gptkbp:treatment
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surgical removal of tumors
medical management of hormone excess
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gptkbp:bfsParent
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gptkb:insulinoma
gptkb:VIPomas
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gptkbp:bfsLayer
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6
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