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gptkbp:instanceOf
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gptkb:genetic_disorder
gptkb:endocrine_neoplasia_syndrome
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gptkbp:alsoKnownAs
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gptkb:Multiple_Endocrine_Neoplasia_type_1
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gptkbp:associatedWith
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gptkb:gastrinoma
gptkb:insulinoma
gptkb:carcinoid_tumors
lipomas
hyperparathyroidism
prolactinoma
adrenocortical tumors
angiofibromas
collagenomas
non-functioning pituitary adenoma
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gptkbp:diagnosedBy
|
genetic testing
biochemical testing
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gptkbp:feature
|
tumors of anterior pituitary gland
tumors of pancreatic islet cells
tumors of parathyroid glands
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gptkbp:firstDescribed
|
1954
Paul Wermer
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gptkbp:geneProduct
|
menin
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gptkbp:inheritance
|
autosomal dominant
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gptkbp:inheritanceRiskToOffspring
|
50%
|
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gptkbp:locatedOnChromosome
|
gptkb:chromosome_11q13
|
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gptkbp:mutationAssociatedWith
|
gptkb:MEN1_gene
|
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gptkbp:OMIM
|
131100
|
|
gptkbp:prevalence
|
1 in 30,000
|
|
gptkbp:riskOfMalignancy
|
increased
|
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gptkbp:treatment
|
surgical removal of tumors
medical management of hormone excess
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gptkbp:bfsParent
|
gptkb:insulinoma
|
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gptkbp:bfsLayer
|
6
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https://www.w3.org/2000/01/rdf-schema#label
|
MEN1 syndrome
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