Lymphocyte function-associated antigen 1 (LFA-1) antagonist
GPTKB entity
Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:antagonist
|
| gptkbp:administered_by |
injection
|
| gptkbp:affects |
T cell activation
B cell function |
| gptkbp:application |
autoimmune diseases
inflammatory diseases |
| gptkbp:associated_with |
chronic diseases
|
| gptkbp:benefits |
reducing inflammation
|
| gptkbp:can_be_combined_with |
other therapies
biologics |
| gptkbp:can_be_used_to |
cancer therapy
combination therapy |
| gptkbp:can_cause |
adverse reactions
|
| gptkbp:clinical_trial |
ongoing
|
| gptkbp:developed_by |
biopharmaceutical companies
treatment of diseases |
| gptkbp:discovered_by |
laboratory studies
|
| gptkbp:enhances |
patient quality of life
therapeutic efficacy treatment outcomes immune checkpoint blockade vaccine responses |
| gptkbp:facilitates |
immune tolerance
|
| gptkbp:has_influence_on |
disease progression
|
| https://www.w3.org/2000/01/rdf-schema#label |
Lymphocyte function-associated antigen 1 (LFA-1) antagonist
|
| gptkbp:impact |
chronic inflammatory conditions
|
| gptkbp:influences |
cytokine production
lymphocyte migration |
| gptkbp:inhibits_binding |
LFA-1 to ICAM-1
|
| gptkbp:initiated_by |
cell adhesion
T cell proliferation monocyte adhesion |
| gptkbp:interacts_with |
other immune modulators
|
| gptkbp:involved_in |
cell signaling pathways
immune response modulation |
| gptkbp:is_effective_against |
certain cancers
|
| gptkbp:is_part_of |
personalized medicine approaches
|
| gptkbp:is_studied_in |
animal models
|
| gptkbp:may_alter |
immune cell trafficking
|
| gptkbp:may_be_evaluated_in |
clinical settings
|
| gptkbp:may_be_investigated_for |
new indications
|
| gptkbp:mechanism_of_action |
blocking LFA-1 interaction
|
| gptkbp:reduces |
symptoms of diseases
autoimmune reactions |
| gptkbp:related_to |
integrins
|
| gptkbp:research_focus |
therapeutic agents
|
| gptkbp:role |
transplant rejection prevention
|
| gptkbp:side_effect |
immune suppression
|
| gptkbp:targets |
LFA-1
|
| gptkbp:used_in |
clinical research
immunology |
| gptkbp:bfsParent |
gptkb:Xiidra
|
| gptkbp:bfsLayer |
6
|