Locked Nucleic Acid (LNA) technology
GPTKB entity
Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
nucleic acid analog technology
|
| gptkbp:amendedBy |
ribose ring
|
| gptkbp:appliesTo |
gene silencing
viral detection mutation detection SNP genotyping mRNA quantification |
| gptkbp:commercialUse |
gptkb:Qiagen
|
| gptkbp:contains |
2'-O,4'-C methylene bridge
|
| gptkbp:developedBy |
gptkb:Exiqon
|
| gptkbp:enables |
high-affinity hybridization
improved stability of oligonucleotides increased specificity |
| gptkbp:firstDescribed |
1998
|
| https://www.w3.org/2000/01/rdf-schema#label |
Locked Nucleic Acid (LNA) technology
|
| gptkbp:improves |
melting temperature of duplexes
nuclease resistance |
| gptkbp:patent |
gptkb:Exiqon
|
| gptkbp:reduces |
off-target effects
|
| gptkbp:usedFor |
in situ hybridization
antisense oligonucleotides PCR probes microRNA detection siRNA design |
| gptkbp:usedIn |
molecular biology
therapeutics diagnostics |
| gptkbp:bfsParent |
gptkb:Exiqon
|
| gptkbp:bfsLayer |
8
|