Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
drug-likeness rule
|
| gptkbp:alsoKnownAs |
Lipinski's Rule of 5
|
| gptkbp:appliesTo |
orally active drugs in humans
|
| gptkbp:criteria |
molecular mass less than 500 daltons
no more than 10 hydrogen bond acceptors no more than 5 hydrogen bond donors octanol-water partition coefficient (log P) not greater than 5 |
| gptkbp:field |
pharmaceutical sciences
medicinal chemistry |
| https://www.w3.org/2000/01/rdf-schema#label |
Lipinski's rule of five
|
| gptkbp:limitation |
exceptions exist for natural products and antibiotics
does not predict pharmacological activity not applicable to all drug types |
| gptkbp:proposedBy |
1997
Christopher A. Lipinski |
| gptkbp:publishedIn |
Advanced Drug Delivery Reviews
|
| gptkbp:purpose |
evaluate drug-likeness
|
| gptkbp:relatedTo |
Rule of three
Veber's rule |
| gptkbp:usedIn |
drug discovery
|
| gptkbp:bfsParent |
gptkb:ChEMBL
|
| gptkbp:bfsLayer |
6
|