Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
local anesthetic
antiarrhythmic agent |
| gptkbp:alsoKnownAs |
gptkb:lidocaine
|
| gptkbp:antidote |
lipid emulsion (for toxicity)
|
| gptkbp:ATCCode |
N01BB02
|
| gptkbp:bioavailability |
100% (IV)
35% (oral) |
| gptkbp:brand |
gptkb:Xylocaine
Lidoderm Lignoderm |
| gptkbp:CASNumber |
137-58-6
|
| gptkbp:category |
amide-type local anesthetic
class 1b antiarrhythmic |
| gptkbp:chemicalFormula |
C14H22N2O
|
| gptkbp:contraindication |
hypersensitivity to amide anesthetics
|
| gptkbp:discoveredBy |
gptkb:Nils_Löfgren
|
| gptkbp:discoveredIn |
1943
|
| gptkbp:excretion |
urine
|
| gptkbp:halfLife |
1.5–2 hours
|
| https://www.w3.org/2000/01/rdf-schema#label |
Lignocaine
|
| gptkbp:IUPACName |
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:marketedAs |
1948
|
| gptkbp:mechanismOfAction |
blocks sodium channels
|
| gptkbp:meltingPoint |
68°C
|
| gptkbp:metabolism |
liver
|
| gptkbp:molecularWeight |
234.34 g/mol
|
| gptkbp:pregnancyCategory |
B (US)
|
| gptkbp:proteinBinding |
60–80%
|
| gptkbp:routeOfAdministration |
injection
topical transdermal intravenous |
| gptkbp:sideEffect |
confusion
tremor seizures drowsiness hypotension bradycardia |
| gptkbp:solubility |
soluble in water
|
| gptkbp:UNII |
98PI200987
|
| gptkbp:usedFor |
local anesthesia
treatment of ventricular arrhythmias |
| gptkbp:usedIn |
cardiology
dentistry dermatology ophthalmology minor surgery ENT procedures |
| gptkbp:WHOModelListOfEssentialMedicines |
true
|
| gptkbp:bfsParent |
gptkb:lidocaine
|
| gptkbp:bfsLayer |
6
|