|
gptkbp:instanceOf
|
gptkb:local_anesthetic
gptkb:antiarrhythmic_agent
|
|
gptkbp:alsoKnownAs
|
gptkb:lidocaine
|
|
gptkbp:antidote
|
lipid emulsion (for toxicity)
|
|
gptkbp:ATCCode
|
N01BB02
|
|
gptkbp:bioavailability
|
100% (IV)
35% (oral)
|
|
gptkbp:brand
|
gptkb:Xylocaine
Lidoderm
Lignoderm
|
|
gptkbp:CASNumber
|
137-58-6
|
|
gptkbp:category
|
amide-type local anesthetic
class 1b antiarrhythmic
|
|
gptkbp:chemicalFormula
|
C14H22N2O
|
|
gptkbp:contraindication
|
hypersensitivity to amide anesthetics
|
|
gptkbp:discoveredBy
|
gptkb:Nils_Löfgren
|
|
gptkbp:discoveredIn
|
1943
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:halfLife
|
1.5–2 hours
|
|
gptkbp:IUPACName
|
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
1948
|
|
gptkbp:mechanismOfAction
|
blocks sodium channels
|
|
gptkbp:meltingPoint
|
68°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
234.34 g/mol
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:proteinBinding
|
60–80%
|
|
gptkbp:routeOfAdministration
|
injection
topical
transdermal
intravenous
|
|
gptkbp:sideEffect
|
confusion
tremor
seizures
drowsiness
hypotension
bradycardia
|
|
gptkbp:solubility
|
soluble in water
|
|
gptkbp:UNII
|
98PI200987
|
|
gptkbp:usedFor
|
local anesthesia
treatment of ventricular arrhythmias
|
|
gptkbp:usedIn
|
cardiology
dentistry
dermatology
ophthalmology
minor surgery
ENT procedures
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:lidocaine
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Lignocaine
|