Lidocaine

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf local anesthetic
antiarrhythmic agent
gptkbp:ATCCode N01BB02
gptkbp:bioavailability 35% (oral)
gptkbp:brand gptkb:Xylocaine
gptkbp:CASNumber 137-58-6
gptkbp:category amide-type local anesthetic
class 1b antiarrhythmic
gptkbp:chemicalFormula C14H22N2O
gptkbp:contraindication hypersensitivity to amide anesthetics
gptkbp:discoveredBy gptkb:Nils_Löfgren
gptkbp:discoveredIn 1943
gptkbp:eliminationHalfLife 1.5–2 hours
gptkbp:excretion gptkb:kidney
gptkbp:first_marketed 1948
gptkbp:hasInChIKey YECGQHPGJNMFTQ-UHFFFAOYSA-N
gptkbp:hasSMILES CCN(CC)CC(=O)Nc1c(C)cccc1C
https://www.w3.org/2000/01/rdf-schema#label Lidocaine
gptkbp:IUPACName 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
gptkbp:KEGGID D00357
gptkbp:legalStatus prescription only
gptkbp:meltingPoint 68–69 °C
gptkbp:MeSH_ID gptkb:D008008
gptkbp:metabolism liver
gptkbp:molecularWeight 234.34 g/mol
gptkbp:origin synthetic
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding 60–80%
gptkbp:PubChem_CID gptkb:CHEMBL1539
gptkb:DB00281
3676
gptkbp:relatedTo gptkb:prilocaine
bupivacaine
mepivacaine
gptkbp:routeOfAdministration injection
topical
transdermal
intravenous
gptkbp:sideEffect confusion
tremor
seizures
drowsiness
hypotension
bradycardia
gptkbp:solubility 4.1 g/L
gptkbp:UNII 98PI200987
gptkbp:usedFor local anesthesia
treatment of ventricular arrhythmias
nerve block
topical pain relief
gptkbp:WHOModelListOfEssentialMedicines included
gptkbp:bfsParent gptkb:Anesthetic
gptkbp:bfsLayer 7