|
gptkbp:instanceOf
|
gptkb:local_anesthetic
gptkb:antiarrhythmic_agent
|
|
gptkbp:ATCCode
|
N01BB02
|
|
gptkbp:bioavailability
|
35% (oral)
|
|
gptkbp:brand
|
gptkb:Xylocaine
|
|
gptkbp:CASNumber
|
137-58-6
|
|
gptkbp:category
|
amide-type local anesthetic
class 1b antiarrhythmic
|
|
gptkbp:chemicalFormula
|
C14H22N2O
|
|
gptkbp:contraindication
|
hypersensitivity to amide anesthetics
|
|
gptkbp:discoveredBy
|
gptkb:Nils_Löfgren
|
|
gptkbp:discoveredIn
|
1943
|
|
gptkbp:eliminationHalfLife
|
1.5–2 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:first_marketed
|
1948
|
|
gptkbp:hasInChIKey
|
YECGQHPGJNMFTQ-UHFFFAOYSA-N
|
|
gptkbp:hasSMILES
|
CCN(CC)CC(=O)Nc1c(C)cccc1C
|
|
gptkbp:IUPACName
|
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
|
|
gptkbp:KEGGID
|
D00357
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:meltingPoint
|
68–69 °C
|
|
gptkbp:MeSH_ID
|
gptkb:D008008
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
234.34 g/mol
|
|
gptkbp:origin
|
synthetic
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:proteinBinding
|
60–80%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1539
gptkb:DB00281
3676
|
|
gptkbp:relatedTo
|
gptkb:prilocaine
bupivacaine
mepivacaine
|
|
gptkbp:routeOfAdministration
|
injection
topical
transdermal
intravenous
|
|
gptkbp:sideEffect
|
confusion
tremor
seizures
drowsiness
hypotension
bradycardia
|
|
gptkbp:solubility
|
4.1 g/L
|
|
gptkbp:UNII
|
98PI200987
|
|
gptkbp:usedFor
|
local anesthesia
treatment of ventricular arrhythmias
nerve block
topical pain relief
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:Anesthetic
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Lidocaine
|