Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gene therapy
|
| gptkbp:administeredBy |
autologous hematopoietic stem cell transplantation
|
| gptkbp:alternativeName |
gptkb:Zynteglo
gptkb:beti-cel |
| gptkbp:approvalYear |
2019
|
| gptkbp:clinicalTrialPhase |
Phase 3
|
| gptkbp:countryOfOrigin |
gptkb:European_Union
|
| gptkbp:deliveredBy |
lentiviral vector
|
| gptkbp:developedBy |
gptkb:bluebird_bio
|
| gptkbp:EMAStatus |
approved
|
| https://www.w3.org/2000/01/rdf-schema#label |
LentiGlobin
|
| gptkbp:mechanismOfAction |
introduces functional HBB gene
|
| gptkbp:regulates |
approved (as beti-cel for beta-thalassemia)
|
| gptkbp:sideEffect |
infections
febrile neutropenia myelosuppression insertional mutagenesis risk |
| gptkbp:targetGene |
gptkb:HBB
|
| gptkbp:treatment |
one-time therapy
|
| gptkbp:usedFor |
gptkb:beta-thalassemia
sickle cell disease |
| gptkbp:bfsParent |
gptkb:bluebird_bio
gptkb:Bluebird_Bio |
| gptkbp:bfsLayer |
7
|