Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
protein
|
| gptkbp:associatedWith |
aging
|
| gptkbp:function |
regulates phosphate and calcium homeostasis
|
| gptkbp:hasPerformedAt |
KL1 and KL2
|
| gptkbp:hasRole |
cognitive function
|
| https://www.w3.org/2000/01/rdf-schema#label |
Klotho
|
| gptkbp:influences |
insulin_signaling
|
| gptkbp:involvedIn |
neurodegenerative diseases
|
| gptkbp:isAssociatedWith |
age-related diseases
diabetes metabolic disorders chronic diseases inflammation cardiovascular health chronic kidney disease neurodegeneration neurodevelopmental disorders endocrine function |
| gptkbp:isConsidered |
a biomarker for aging
|
| gptkbp:isExaminedBy |
KLOTHO_gene
|
| gptkbp:isInvolvedIn |
cellular homeostasis
cellular metabolism cellular stress response immune response neuroinflammation stress response cell signaling pathways cellular senescence oxidative stress response cellular aging cellular differentiation neuroprotection hormonal regulation cellular signaling pathways neurotransmitter regulation cellular communication cellular signaling cellular repair mechanisms cell growth regulation vascular aging vascular_health |
| gptkbp:isLinkedTo |
cognitive decline
metabolic syndrome kidney function longevity muscle health bone metabolism metabolic health hormonal balance cardiac health neuroprotection mechanisms |
| gptkbp:isLocatedIn |
brain
liver pancreas placenta various tissues lungs skin adipose tissue heart intestine |
| gptkbp:isRegulatedBy |
FGF23
|
| gptkbp:isStudiedIn |
its role in cancer
mouse_models |
| gptkbp:isTrainedIn |
therapeutic interventions
|
| gptkbp:locatedIn |
blood
|
| gptkbp:mayHave |
Wnt signaling pathway
|
| gptkbp:producedBy |
kidneys
|