|
gptkbp:instanceOf
|
gptkb:immunoglobulin_G_subclass
|
|
gptkbp:associatedWith
|
IgG4-related disease
autoimmune pancreatitis
|
|
gptkbp:canBe
|
Fab-arm exchange
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:doesNotActivate
|
classical complement pathway
|
|
gptkbp:encodedBy
|
IGHG4 gene
|
|
gptkbp:features
|
does not form large immune complexes
dynamic Fab-arm exchange
limited ability to bind Fc receptors
|
|
gptkbp:foundIn
|
gptkb:human
|
|
gptkbp:function
|
immune response modulation
anti-inflammatory activity
|
|
gptkbp:halfLife
|
21 days
|
|
gptkbp:heavyChainType
|
gamma-4
|
|
gptkbp:isotypeOf
|
gptkb:IgG
|
|
gptkbp:lightChainType
|
lambda
kappa
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_14q32.33
|
|
gptkbp:medicalUse
|
biomarker for IgG4-related disease
diagnosis of autoimmune pancreatitis
|
|
gptkbp:molecularWeight
|
146 kDa
|
|
gptkbp:percentageOfTotalIgG
|
3–6%
|
|
gptkbp:serumConcentration
|
0.35–0.51 mg/mL
|
|
gptkbp:structure
|
two heavy chains and two light chains
|
|
gptkbp:bfsParent
|
gptkb:Protein_A
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IgG4 subclass (human)
|