Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
immunoglobulin G subclass
|
| gptkbp:associatedWith |
IgG4-related disease
autoimmune pancreatitis |
| gptkbp:canBe |
Fab-arm exchange
|
| gptkbp:discoveredIn |
1970s
|
| gptkbp:doesNotActivate |
classical complement pathway
|
| gptkbp:encodedBy |
IGHG4 gene
|
| gptkbp:features |
does not form large immune complexes
dynamic Fab-arm exchange limited ability to bind Fc receptors |
| gptkbp:foundIn |
gptkb:human
|
| gptkbp:function |
immune response modulation
anti-inflammatory activity |
| gptkbp:halfLife |
21 days
|
| gptkbp:heavyChainType |
gamma-4
|
| https://www.w3.org/2000/01/rdf-schema#label |
IgG4 subclass (human)
|
| gptkbp:isotypeOf |
gptkb:IgG
|
| gptkbp:lightChainType |
lambda
kappa |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_14q32.33
|
| gptkbp:medicalUse |
biomarker for IgG4-related disease
diagnosis of autoimmune pancreatitis |
| gptkbp:molecularWeight |
146 kDa
|
| gptkbp:percentageOfTotalIgG |
3–6%
|
| gptkbp:serumConcentration |
0.35–0.51 mg/mL
|
| gptkbp:structure |
two heavy chains and two light chains
|
| gptkbp:bfsParent |
gptkb:Protein_A
|
| gptkbp:bfsLayer |
7
|