|
gptkbp:instanceOf
|
gptkb:monoclonal_antibody
|
|
gptkbp:binds
|
antigens
|
|
gptkbp:canActivate
|
complement system (alternative and lectin pathways)
|
|
gptkbp:deficiencyAssociatedWith
|
autoimmune diseases
recurrent infections
|
|
gptkbp:discoveredBy
|
E. A. Kabat
|
|
gptkbp:discoveredIn
|
1953
|
|
gptkbp:foundIn
|
gastrointestinal tract
mucous membranes
breast milk
tears
saliva
respiratory tract
urogenital tract
|
|
gptkbp:fullName
|
Immunoglobulin A
|
|
gptkbp:function
|
immune defense at mucosal surfaces
|
|
gptkbp:halfLife
|
5-6 days
|
|
gptkbp:heavyChainType
|
alpha chain
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IgA antibody
|
|
gptkbp:importantFor
|
mucosal immunity
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_14
|
|
gptkbp:molecularWeight
|
~160 kDa (monomer)
~385 kDa (dimer)
|
|
gptkbp:notEfficientAt
|
activating classical complement pathway
|
|
gptkbp:percentageOfTotalImmunoglobulin
|
about 10-15%
|
|
gptkbp:presentIn
|
secretory component
|
|
gptkbp:prevention
|
pathogen adherence
|
|
gptkbp:producedBy
|
plasma cells
|
|
gptkbp:secretes
|
secretory IgA (sIgA)
|
|
gptkbp:structure
|
dimer
monomer
|
|
gptkbp:subclassOf
|
IgA1
IgA2
|
|
gptkbp:bfsParent
|
gptkb:Henoch–Schönlein_purpura
|
|
gptkbp:bfsLayer
|
6
|