| gptkbp:instanceOf | gptkb:vaccine 
 | 
                        
                            
                                | gptkbp:administeredBy | adolescents adults
 infants
 healthcare workers
 travelers to endemic areas
 people with chronic liver disease
 people at risk of exposure to blood
 
 | 
                        
                            
                                | gptkbp:approvedBy | gptkb:World_Health_Organization gptkb:U.S._Food_and_Drug_Administration
 1981
 
 | 
                        
                            
                                | gptkbp:boosterRecommended | not routinely 
 | 
                        
                            
                                | gptkbp:broadcastOn | 0, 1, 6 months (adults) birth, 1-2 months, 6-18 months (infants)
 
 | 
                        
                            
                                | gptkbp:category | public health immunization
 essential medicine
 
 | 
                        
                            
                                | gptkbp:contains | hepatitis B surface antigen 
 | 
                        
                            
                                | gptkbp:contraindication | severe allergic reaction to previous dose 
 | 
                        
                            
                                | gptkbp:countryOfOrigin | gptkb:China gptkb:Italy
 gptkb:United_States
 
 | 
                        
                            
                                | gptkbp:discoveredBy | gptkb:Baruch_Blumberg gptkb:Irving_Millman
 
 | 
                        
                            
                                | gptkbp:immunityDuration | at least 20 years 
 | 
                        
                            
                                | gptkbp:includedIn | gptkb:Expanded_Programme_on_Immunization 
 | 
                        
                            
                                | gptkbp:marketedAs | gptkb:Recombivax_HB gptkb:Engerix-B
 gptkb:Heplisav-B
 Twinrix (combined with hepatitis A vaccine)
 
 | 
                        
                            
                                | gptkbp:pregnancyCategory | safe 
 | 
                        
                            
                                | gptkbp:prevention | gptkb:Hepatitis_B 
 | 
                        
                            
                                | gptkbp:routeOfAdministration | intramuscular injection 
 | 
                        
                            
                                | gptkbp:sideEffect | fatigue mild fever
 soreness at injection site
 
 | 
                        
                            
                                | gptkbp:storage | 2-8°C 
 | 
                        
                            
                                | gptkbp:type | recombinant vaccine subunit vaccine
 
 | 
                        
                            
                                | gptkbp:usedIn | healthcare worker immunization high-risk adult immunization
 universal childhood immunization
 
 | 
                        
                            
                                | gptkbp:WHOModelListOfEssentialMedicines | true 
 | 
                        
                            
                                | gptkbp:bfsParent | gptkb:Hepatitis_B_surface_antigen_(Australia_antigen) gptkb:Chiron_Corporation
 
 | 
                        
                            
                                | gptkbp:bfsLayer | 6 
 | 
                        
                            
                                | https://www.w3.org/2000/01/rdf-schema#label | Hepatitis B vaccine 
 |