Properties (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
enzyme
|
| gptkbp:associatedWith |
adverse drug reactions
drug interactions |
| gptkbp:clinicalTrials |
personalized medicine
pharmacogenomics |
| gptkbp:contains |
heme group
|
| gptkbp:family |
cytochrome P450
|
| gptkbp:function |
catalyze oxidation reactions
|
| gptkbp:geneticDiversity |
CYP2D6
CYP3A4 CYP2C19 |
| https://www.w3.org/2000/01/rdf-schema#label |
HMS P450
|
| gptkbp:introduced |
gptkb:St._John's_Wort
gptkb:carbamazepine phenobarbital |
| gptkbp:involvedIn |
drug metabolism
steroid synthesis |
| gptkbp:is_a_route_for |
cholesterol metabolism
amino acid metabolism phase I metabolism xenobiotic metabolism nucleotide metabolism vitamin D metabolism fatty acid metabolism sugar metabolism antioxidant metabolism bile acid synthesis carcinogen activation cell signaling. drug clearance eicosanoid synthesis hormone metabolism neurotransmitter metabolism retinoic acid metabolism steroid hormone biosynthesis |
| gptkbp:isActiveIn |
ketoconazole
rifampicin cimetidine |
| gptkbp:locatedIn |
1960s
liver |
| gptkbp:regulatoryBody |
fatty acids
vitamins steroids xenobiotics |
| gptkbp:research |
molecular biology
biochemistry toxicology drug development structural biology metabolomics enzyme kinetics |
| gptkbp:role |
detoxification
activation of prodrugs metabolism of endogenous compounds |