Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
|
| gptkbp:application |
organic synthesis
pharmaceutical synthesis alcohol preparation |
| gptkbp:discoveredBy |
gptkb:François_Auguste_Victor_Grignard
|
| gptkbp:discoveredIn |
1900
|
| gptkbp:exampleGrignardReagent |
ethylmagnesium chloride
methylmagnesium bromide phenylmagnesium bromide |
| gptkbp:field |
organic chemistry
|
| https://www.w3.org/2000/01/rdf-schema#label |
Grignard reaction
|
| gptkbp:involvesReagent |
gptkb:Grignard_reagent
|
| gptkbp:limitation |
incompatible with air
incompatible with protic functional groups incompatible with water |
| gptkbp:mainReagent |
organomagnesium halide
|
| gptkbp:mainSolvent |
Ether
|
| gptkbp:namedAfter |
gptkb:François_Auguste_Victor_Grignard
|
| gptkbp:NobelPrizeYear |
gptkb:François_Auguste_Victor_Grignard
1912 Chemistry |
| gptkbp:product |
gptkb:beer
secondary alcohol primary alcohol tertiary alcohol |
| gptkbp:reactant |
aldehyde
ketone carbonyl compound |
| gptkbp:reactionMechanism |
nucleophilic attack on carbonyl carbon
|
| gptkbp:relatedTo |
gptkb:Barbier_reaction
organolithium addition |
| gptkbp:requires |
dry ether
anhydrous conditions |
| gptkbp:sensitivity |
moisture sensitive
|
| gptkbp:sideProduct |
magnesium salt
|
| gptkbp:step |
acidic workup
addition to carbonyl compound formation of Grignard reagent |
| gptkbp:type |
carbon-carbon bond formation
nucleophilic addition |
| gptkbp:usedFor |
synthesis of complex molecules
introduction of alkyl groups introduction of aryl groups introduction of vinyl groups |
| gptkbp:usedIn |
industrial chemistry
laboratory synthesis |
| gptkbp:yield |
alcohol after hydrolysis
|
| gptkbp:bfsParent |
gptkb:Organic_Chemistry
gptkb:Victor_Grignard |
| gptkbp:bfsLayer |
6
|