|
gptkbp:instanceOf
|
gptkb:drug
loop diuretic
|
|
gptkbp:ATCCode
|
C03CA01
|
|
gptkbp:availableOn
|
gptkb:tablet
oral solution
solution for injection
|
|
gptkbp:bioavailability
|
60% (oral)
|
|
gptkbp:CASNumber
|
54-31-9
|
|
gptkbp:chemicalFormula
|
C12H11ClN2O5S
|
|
gptkbp:color
|
white (powder)
|
|
gptkbp:contraindication
|
sulfa allergy
anuria
|
|
gptkbp:discoveredBy
|
gptkb:F._Hoffmann-La_Roche
|
|
gptkbp:eliminationHalfLife
|
1.5 hours
|
|
gptkbp:essentialMedicine
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:excretion
|
urine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Furosemide
|
|
gptkbp:introducedIn
|
1962
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits Na-K-2Cl symporter in thick ascending limb of loop of Henle
|
|
gptkbp:meltingPoint
|
206°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:otherName
|
Frusemide
Lasix
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:prescribes
|
gptkb:hypercalcemia
acute renal failure
nephrotic syndrome
acute pulmonary edema
|
|
gptkbp:proteinBinding
|
95%
|
|
gptkbp:PubChem_CID
|
3440
DB00695
|
|
gptkbp:riskFactor
|
gout
renal dysfunction
electrolyte imbalance
|
|
gptkbp:routeOfAdministration
|
oral
intramuscular
intravenous
|
|
gptkbp:sideEffect
|
dehydration
hypokalemia
hypotension
ototoxicity
hyperuricemia
metabolic alkalosis
|
|
gptkbp:solubility
|
slightly soluble
|
|
gptkbp:synonym
|
4-chloro-N-furfuryl-5-sulfamoylanthranilic acid
|
|
gptkbp:UNII
|
7LXU5N7ZO5
|
|
gptkbp:usedFor
|
congestive heart failure
edema
hypertension
chronic kidney disease
liver cirrhosis
|
|
gptkbp:bfsParent
|
gptkb:Water_Tablet
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|