Statements (18)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
physical phenomenon
|
| gptkbp:alsoKnownAs |
gptkb:molecular_Koch's_postulates
|
| gptkbp:appliesTo |
bacterial virulence factors
|
| gptkbp:field |
microbiology
|
| gptkbp:firstPostulate |
The phenotype or property under investigation should be associated with pathogenic members of a genus or pathogenic strains of a species.
|
| https://www.w3.org/2000/01/rdf-schema#label |
Falkow's postulates
|
| gptkbp:inspiredBy |
gptkb:Koch's_postulates
|
| gptkbp:numberOfPostulates |
three
|
| gptkbp:proposedBy |
gptkb:Stanley_Falkow
|
| gptkbp:purpose |
to identify genes responsible for pathogenicity
|
| gptkbp:secondPostulate |
Specific inactivation of the gene(s) associated with the suspected virulence trait should lead to a measurable loss in pathogenicity or virulence.
|
| gptkbp:significance |
establishes a genetic basis for microbial pathogenicity
|
| gptkbp:thirdPostulate |
Reversion or allelic replacement of the mutated gene should lead to restoration of pathogenicity.
|
| gptkbp:usedIn |
infectious disease research
molecular microbiology |
| gptkbp:yearProposed |
1988
|
| gptkbp:bfsParent |
gptkb:molecular_Koch's_postulates
|
| gptkbp:bfsLayer |
6
|