Statements (67)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:anatomy |
epithelial cells
|
| gptkbp:antibody_target |
therapeutic antibodies
|
| gptkbp:application |
cell differentiation
|
| gptkbp:associated_with |
gptkb:Oncology
epidermal growth factor poor prognosis |
| gptkbp:cell_line_model |
used in research
|
| gptkbp:cell_proliferation |
stimulated by ligands
|
| gptkbp:cell_signaling |
autocrine signaling
|
| gptkbp:cellular_localization |
plasma membrane
|
| gptkbp:cellular_response |
stimulated by EGF
|
| gptkbp:chromosome_location |
7p11.2
|
| gptkbp:clinical_trial |
ongoing studies
biomarker for cancer treatment |
| gptkbp:clinical_use |
personalized medicine
|
| gptkbp:discovered_by |
gptkb:Human
|
| gptkbp:diseases |
gptkb:Oncology
|
| gptkbp:ecological_role |
mediates cellular responses
|
| gptkbp:expression_analysis |
used in tumor profiling
|
| gptkbp:expression_assay |
used in diagnostics
|
| gptkbp:expression_level |
varies in tumors
|
| gptkbp:family |
receptor tyrosine kinases
|
| gptkbp:function |
involved in cell signaling
|
| gptkbp:genetic_studies |
point mutations
associated with resistance to therapy altered signaling |
| https://www.w3.org/2000/01/rdf-schema#label |
EGPR
|
| gptkbp:inhibitor_example |
cetuximab
|
| gptkbp:inhibitor_mechanism |
blocks receptor activation
|
| gptkbp:inhibitor_type |
small molecules
|
| gptkbp:inhibitory_mechanism |
competitive inhibition
|
| gptkbp:initiated_by |
dimerization
EGFR inhibitors |
| gptkbp:interacts_with |
ligands
|
| gptkbp:involved_in |
tumor growth
|
| gptkbp:is_expressed_in |
upregulated in tumors
varies by tissue type increased in metastatic cancer |
| gptkbp:ligand_binding |
high affinity
|
| gptkbp:ligand_interaction |
EGF and TGF-alpha
|
| gptkbp:ligand_specificity |
specific to EGF family
|
| gptkbp:location |
cell membrane
|
| gptkbp:mutation_impact |
affects treatment response
|
| gptkbp:nutritional_value |
extracellular domain
|
| gptkbp:pathway |
MAPK signaling pathway
PI3 K/ AKT pathway |
| gptkbp:phosphorylation_sites |
multiple sites
|
| gptkbp:promoter |
EGFR gene
|
| gptkbp:regulatory_compliance |
transcription factors
|
| gptkbp:related_products |
EGF
|
| gptkbp:related_to |
gptkb:Oncology
|
| gptkbp:research |
growth factor receptor activity
|
| gptkbp:research_areas |
oncology
ongoing research cancer immunotherapy targeting EGFR signaling |
| gptkbp:research_focus |
target for drug development
biomarkers in cancer |
| gptkbp:role |
promotes cell proliferation
|
| gptkbp:signal_transduction |
phosphorylation
|
| gptkbp:targeted_therapy |
EGFR-targeted therapy
|
| gptkbp:targets |
monoclonal antibodies
|
| gptkbp:therapeutic_strategy |
combination therapy
|
| gptkbp:type |
gptkb:fusion
|
| gptkbp:bfsParent |
gptkb:Barra_Airport
|
| gptkbp:bfsLayer |
7
|