Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
protein
|
| gptkbp:associated_with |
gptkb:esophageal_cancer
ovarian cancer lung cancer breast cancer cervical cancer pancreatic cancer prostate cancer gastric cancer bladder cancer head and neck cancer |
| gptkbp:associatedWith |
cell differentiation
cell proliferation tumor growth |
| gptkbp:clinicalTrials |
glioblastoma
breast cancer colorectal cancer head and neck cancers non-small cell lung cancer |
| gptkbp:community |
regulated by hypoxia
regulated by oncogenes overexpressed in tumors regulated by tumor suppressors |
| gptkbp:function |
receptor for epidermal growth factor
|
| gptkbp:geneticDiversity |
gptkb:EGFR
L858R T790M del19 |
| https://www.w3.org/2000/01/rdf-schema#label |
EGPR
|
| gptkbp:involvedIn |
tumor microenvironment
cell migration tumor progression tumor angiogenesis chemoresistance radiation resistance invasion immune evasion metabolic reprogramming tumor metastasis angiogenic switch |
| gptkbp:is_a_route_for |
MAPK pathway
PI3K/AKT pathway |
| gptkbp:isActiveIn |
gptkb:erlotinib
gefitinib cetuximab |
| gptkbp:location |
cell membrane
|
| gptkbp:related_to |
gptkb:amphiregulin
gptkb:betacellulin EGF TGF-alpha neuregulin |
| gptkbp:research_areas |
monoclonal antibodies
targeted therapy small molecule inhibitors |
| gptkbp:role |
signal transduction
cell survival angiogenesis metastasis |