membrane‑spanning 4‑domains subfamily A (MS4A)

Target entity: membrane‑spanning 4‑domains subfamily A (MS4A)
Context triple: [CD20 protein, belongsToFamily, membrane‑spanning 4‑domains subfamily A (MS4A)]

• A. CD20 protein
  CD20 protein is a cell-surface antigen found primarily on B lymphocytes and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
• B. CD46
  CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
• C. MASP
  MASP (Museu de Arte de São Paulo) is one of Brazil’s most important art museums, renowned for its striking modernist architecture and extensive collection of Western and Brazilian art.
• D. Bruton tyrosine kinase
  Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
• E. M2 muscarinic acetylcholine receptor
  The M2 muscarinic acetylcholine receptor is a G protein–coupled receptor subtype primarily found in the heart, where it mediates parasympathetic (vagal) effects such as slowing heart rate and reducing contractility.
• F. None of above. chosen
• G. Unsure - the case is ambiguous/there is not enough information to decide.

Target entity: membrane‑spanning 4‑domains subfamily A (MS4A)
Target entity description: Membrane-spanning 4-domains subfamily A (MS4A) is a family of tetraspan membrane proteins, including CD20, that are primarily involved in immune cell signaling and regulation.

• A. CD20 protein
  CD20 protein is a cell-surface antigen found primarily on B lymphocytes and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
• B. CD46
  CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
• C. MASP
  MASP (Museu de Arte de São Paulo) is one of Brazil’s most important art museums, renowned for its striking modernist architecture and extensive collection of Western and Brazilian art.
• D. Bruton tyrosine kinase
  Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
• E. M2 muscarinic acetylcholine receptor
  The M2 muscarinic acetylcholine receptor is a G protein–coupled receptor subtype primarily found in the heart, where it mediates parasympathetic (vagal) effects such as slowing heart rate and reducing contractility.
• F. None of above. chosen