GNAI2 gene (for Gαi2 in humans)

E876001

protein-coding gene

The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.

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All labels observed (7)

Label	Occurrences
G alpha i2 protein	1
G protein alpha inhibiting activity polypeptide 2	1
G protein subunit alpha i2	1
GNAI2 gene	1
GNAI2 gene (for Gαi2 in humans) canonical	1
Gnai2 (mouse)	1
Gαi2 gene	1

How this entity was disambiguated

This entity first appeared as the object of triple T10610034 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: GNAI2 gene (for Gαi2 in humans)
Context triple: [Gi protein, encodedBy, GNAI2 gene (for Gαi2 in humans)]

A. Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
B. GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
C. ABCG2 gene
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
D. Gi-coupled GPCR
A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
E. HTT gene
The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: GNAI2 gene (for Gαi2 in humans)
Target entity description: The GNAI2 gene encodes the Gαi2 alpha subunit of heterotrimeric G proteins in humans, a key regulator that inhibits adenylyl cyclase and modulates diverse hormone and neurotransmitter signaling pathways.

A. Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
B. GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
C. ABCG2 gene
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
D. Gi-coupled GPCR
A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
E. HTT gene
The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
F. None of above. chosen

Statements (48)

Predicate	Object
instanceOf	protein-coding gene ⓘ
activatedBy	G protein–coupled receptors ⓘ guanine nucleotide exchange from GDP to GTP ⓘ
alias	G protein alpha inhibiting activity polypeptide 2 ⓘ linked to: GNAI2 gene (for Gαi2 in humans) GNAI2 gene ⓘ linked to: GNAI2 gene (for Gαi2 in humans) Gαi2 gene ⓘ linked to: GNAI2 gene (for Gαi2 in humans)
associatedWith	cardiovascular signaling pathways ⓘ immune cell signaling ⓘ neural signaling pathways ⓘ pertussis toxin–sensitive G protein signaling ⓘ
biologicalProcess	G protein–coupled receptor signaling pathway, coupled to inhibition of adenylate cyclase ⓘ inhibition of adenylate cyclase activity ⓘ regulation of cAMP biosynthetic process ⓘ regulation of hormone-mediated signaling pathway ⓘ regulation of neurotransmitter signaling ⓘ signal transduction ⓘ
cellularComponent	cytoplasm ⓘ heterotrimeric G protein complex ⓘ plasma membrane ⓘ
encodes	G alpha i2 protein ⓘ linked to: GNAI2 gene (for Gαi2 in humans) G protein subunit alpha i2 ⓘ linked to: GNAI2 gene (for Gαi2 in humans) Gαi2 alpha subunit ⓘ
expressedIn	brain ⓘ heart ⓘ immune cells ⓘ
geneType	protein coding ⓘ
hasDomain	GTP-binding P-loop NTPase domain ⓘ
hasOrtholog	Gnai2 (mouse) ⓘ linked to: GNAI2 gene (for Gαi2 in humans) Gnai2 (rat) ⓘ
inactivatedBy	intrinsic GTPase activity ⓘ regulators of G protein signaling proteins ⓘ
locatedOnChromosome	human chromosome 3 ⓘ
molecularFunction	GDP binding ⓘ GTP binding ⓘ GTPase activity ⓘ adenylyl cyclase inhibitor activity ⓘ
organism	Homo sapiens ⓘ
participatesIn	G protein–coupled receptor signaling pathway ⓘ heterotrimeric G protein signaling pathway ⓘ
postTranslationalModification	myristoylation of Gαi2 protein ⓘ palmitoylation of Gαi2 protein ⓘ
regulates	adenylyl cyclase ⓘ cAMP levels ⓘ hormone receptor signaling ⓘ ion channel activity ⓘ neurotransmitter receptor signaling ⓘ
subunitOf	G alpha i/o family ⓘ linked to: Gi protein Gi heterotrimeric G protein ⓘ linked to: Gi protein