MAGL enzyme
E874321
MAGL enzyme is a key serine hydrolase that terminates endocannabinoid signaling by hydrolyzing 2-arachidonoylglycerol (2-AG) into arachidonic acid and glycerol.
All labels observed (3)
| Label | Occurrences |
|---|---|
| MAGL enzyme canonical | 1 |
| monoacylglycerol lipase | 1 |
| monoacylglycerol lipase (EC 3.1.1.23) | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10610192 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: MAGL enzyme Context triple: [endocannabinoid system, hasPart, MAGL enzyme]
-
A.
rimonabant
Rimonabant is a selective cannabinoid CB1 receptor antagonist that was developed as an anti-obesity drug but withdrawn due to psychiatric side effects.
-
B.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
C.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
D.
Flavin
Flavin is a surname most notably associated with American minimalist artist Dan Flavin, renowned for his fluorescent light installations.
-
E.
Branigin
Branigin is a surname most notably associated with Roger D. Branigin, who served as the 42nd governor of Indiana.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: MAGL enzyme Target entity description: MAGL enzyme is a key serine hydrolase that terminates endocannabinoid signaling by hydrolyzing 2-arachidonoylglycerol (2-AG) into arachidonic acid and glycerol.
-
A.
rimonabant
Rimonabant is a selective cannabinoid CB1 receptor antagonist that was developed as an anti-obesity drug but withdrawn due to psychiatric side effects.
-
B.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
C.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
D.
Flavin
Flavin is a surname most notably associated with American minimalist artist Dan Flavin, renowned for his fluorescent light installations.
-
E.
Branigin
Branigin is a surname most notably associated with Roger D. Branigin, who served as the 42nd governor of Indiana.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
enzyme
ⓘ
serine hydrolase ⓘ |
| abbreviation | MAGL ⓘ |
| associatedWith |
cancer progression
ⓘ
neurodegenerative diseases ⓘ neuroinflammation ⓘ pain modulation ⓘ |
| biologicalProcess |
eicosanoid precursor generation
ⓘ
endocannabinoid metabolism ⓘ lipid catabolic process ⓘ termination of endocannabinoid signaling ⓘ |
| catalyticActivity | monoacylglycerol + H2O → glycerol + fatty acid ⓘ |
| catalyticResidue | serine ⓘ |
| chromosomalLocation | human chromosome 3q21.3 ⓘ |
| cofactorRequirement | does not require cofactors ⓘ |
| drugTargetFor |
analgesic agents
ⓘ
anti-inflammatory agents ⓘ anticancer agents ⓘ neuroprotective agents ⓘ |
| ECNumber | 3.1.1.23 ⓘ |
| enzymeClass |
hydrolase
ⓘ
lipase ⓘ |
| family | α/β-hydrolase fold enzymes ⓘ |
| fullName |
monoacylglycerol lipase
ⓘ
linked to:
MAGL enzyme
|
| geneName | MGLL ⓘ |
| inhibitedBy |
JZL184
ⓘ
KML29 ⓘ MJN110 ⓘ URB602 ⓘ organophosphorus inhibitors ⓘ |
| localization |
cell membrane-associated
ⓘ
cytosol ⓘ |
| molecularWeight | approximately 33 kDa ⓘ |
| oligomericState | homodimer ⓘ |
| organism | Homo sapiens ⓘ |
| pathway |
arachidonic acid metabolism
ⓘ
endocannabinoid signaling pathway ⓘ |
| primaryFunction | hydrolyzes monoacylglycerols ⓘ |
| product |
arachidonic acid
ⓘ
glycerol ⓘ |
| regulates |
2-arachidonoylglycerol levels
ⓘ
CB1 receptor signaling ⓘ CB2 receptor signaling ⓘ |
| substrate |
2-arachidonoylglycerol
ⓘ
monoacylglycerols ⓘ |
| systematicName |
monoacylglycerol lipase (EC 3.1.1.23)
ⓘ
linked to:
MAGL enzyme
|
| tissueExpression |
adipose tissue
ⓘ
brain ⓘ gastrointestinal tract ⓘ liver ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: MAGL enzyme Description of subject: MAGL enzyme is a key serine hydrolase that terminates endocannabinoid signaling by hydrolyzing 2-arachidonoylglycerol (2-AG) into arachidonic acid and glycerol.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
MAGL enzyme
linked to: MAGL enzyme