somatostatin receptor
E874317
A somatostatin receptor is a G protein–coupled membrane receptor that binds the peptide hormone somatostatin to inhibit hormone secretion and modulate neurotransmission and cell proliferation.
All labels observed (2)
| Label | Occurrences |
|---|---|
| SSTR2 | 1 |
| somatostatin receptor canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10610023 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: somatostatin receptor Context triple: [Gi protein, couplesToReceptor, somatostatin receptor]
-
A.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
B.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
C.
SERT
SERT is the abbreviation for the Special Emergency Reaction Team, a specialized law enforcement unit trained to respond to high-risk and critical incidents.
-
D.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
-
E.
constitutive androstane receptor
The constitutive androstane receptor (CAR) is a nuclear receptor that senses xenobiotics and endogenous compounds to regulate the expression of drug-metabolizing enzymes and transporters in the liver.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: somatostatin receptor Target entity description: A somatostatin receptor is a G protein–coupled membrane receptor that binds the peptide hormone somatostatin to inhibit hormone secretion and modulate neurotransmission and cell proliferation.
-
A.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
B.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
C.
SERT
SERT is the abbreviation for the Special Emergency Reaction Team, a specialized law enforcement unit trained to respond to high-risk and critical incidents.
-
D.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
-
E.
constitutive androstane receptor
The constitutive androstane receptor (CAR) is a nuclear receptor that senses xenobiotics and endogenous compounds to regulate the expression of drug-metabolizing enzymes and transporters in the liver.
- F. None of above. chosen
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf |
G protein–coupled receptor
ⓘ
membrane receptor ⓘ neurotransmitter receptor ⓘ protein family ⓘ |
| belongsToPathway |
G protein–coupled receptor signaling pathway
ⓘ
inhibitory G protein signaling pathway ⓘ |
| couplesTo |
Gi protein
ⓘ
Go protein ⓘ |
| hasBiologicalProcess |
inhibition of adenylate cyclase activity
ⓘ
inhibition of hormone secretion ⓘ modulation of neurotransmission ⓘ regulation of calcium channel activity ⓘ regulation of cell proliferation ⓘ regulation of potassium channel activity ⓘ |
| hasCellularLocation |
cell surface
ⓘ
plasma membrane ⓘ |
| hasComponent | seven transmembrane helices ⓘ |
| hasLigand |
DOTATATE
ⓘ
DOTATOC ⓘ lanreotide ⓘ
linked to:
Somatuline
octreotide ⓘ pasireotide ⓘ somatostatin ⓘ somatostatin-14 ⓘ somatostatin-28 ⓘ |
| hasMolecularFunction |
G protein–coupled receptor activity
ⓘ
signal transducer activity ⓘ somatostatin binding ⓘ |
| hasSubtype |
SSTR1
ⓘ
SSTR2 ⓘ
linked to:
somatostatin receptor
SSTR3 ⓘ SSTR4 ⓘ SSTR5 ⓘ |
| isEncodedBy |
SSTR1 gene
ⓘ
SSTR2 gene ⓘ SSTR3 gene ⓘ
linked to:
SSTR3
SSTR4 gene ⓘ
linked to:
SSTR4
SSTR5 gene ⓘ
linked to:
SSTR5
|
| isExpressedIn |
central nervous system
ⓘ
endocrine tumors ⓘ gastrointestinal tract ⓘ hypothalamus ⓘ pancreatic islet cells ⓘ pituitary gland ⓘ |
| isTargetOf |
peptide receptor radionuclide therapy
ⓘ
radiolabeled diagnostic agents ⓘ somatostatin analogs ⓘ |
| isUsedIn |
imaging of neuroendocrine tumors
ⓘ
treatment of acromegaly ⓘ treatment of neuroendocrine tumors ⓘ |
| negativelyRegulates |
cell proliferation
ⓘ
cyclic AMP biosynthetic process ⓘ hormone secretion ⓘ neurotransmitter release ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: somatostatin receptor Description of subject: A somatostatin receptor is a G protein–coupled membrane receptor that binds the peptide hormone somatostatin to inhibit hormone secretion and modulate neurotransmission and cell proliferation.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: somatostatin receptor