CD46
E854992
CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
All labels observed (3)
| Label | Occurrences |
|---|---|
| CD46 canonical | 1 |
| CD46 (for some serotypes) | 1 |
| CD46 gene | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10292290 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CD46 Context triple: [human adenovirus serotype 26, targetCellEntryReceptor, CD46]
-
A.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
-
B.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
-
C.
CD3 complex
The CD3 complex is a multi-subunit protein complex associated with the T-cell receptor that is essential for T-cell activation and signal transduction in the immune system.
-
D.
CD32
CD32 is a low-affinity Fc gamma receptor (FcγRII) found on various immune cells that plays a key role in modulating antibody-dependent immune responses.
-
E.
CD20 protein
CD20 protein is a cell-surface antigen found primarily on B lymphocytes and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CD46 Target entity description: CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
-
A.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
-
B.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
-
C.
CD3 complex
The CD3 complex is a multi-subunit protein complex associated with the T-cell receptor that is essential for T-cell activation and signal transduction in the immune system.
-
D.
CD32
CD32 is a low-affinity Fc gamma receptor (FcγRII) found on various immune cells that plays a key role in modulating antibody-dependent immune responses.
-
E.
CD20 protein
CD20 protein is a cell-surface antigen found primarily on B lymphocytes and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
cell-surface receptor
ⓘ
complement regulatory protein ⓘ glycoprotein ⓘ human protein ⓘ membrane protein ⓘ |
| actsAsReceptorFor |
Neisseria gonorrhoeae
ⓘ
Neisseria meningitidis ⓘ Streptococcus pyogenes ⓘ
linked to:
Streptococcus
certain adenoviruses ⓘ human herpesvirus 6 ⓘ measles virus ⓘ |
| associatedWith |
age-related macular degeneration
ⓘ
atypical hemolytic uremic syndrome ⓘ pregnancy complications ⓘ |
| binds |
C3b
ⓘ
C4b ⓘ |
| chromosomalLocation | 1q32 ⓘ |
| discoveredAs | complement regulatory protein on human cells ⓘ |
| encodedBy |
CD46 gene
ⓘ
linked to:
CD46
|
| expressedOn |
endothelial cells
ⓘ
epithelial cells ⓘ leukocytes ⓘ nucleated human cells ⓘ spermatozoa ⓘ |
| foundInSpecies | Homo sapiens ⓘ |
| hasAbbreviation | MCP ⓘ |
| hasDomain | complement control protein domain ⓘ |
| hasFunction |
cofactor activity for factor I–mediated cleavage of C3b
ⓘ
cofactor activity for factor I–mediated cleavage of C4b ⓘ regulation of complement activation ⓘ |
| hasIsoform |
CD46 isoform with CYT-1 cytoplasmic tail
ⓘ
CD46 isoform with CYT-2 cytoplasmic tail ⓘ |
| hasPostTranslationalModification |
N-linked glycosylation
ⓘ
O-linked glycosylation ⓘ |
| hasRegion |
cytoplasmic tail
ⓘ
extracellular domain ⓘ transmembrane domain ⓘ |
| hasSynonym | membrane cofactor protein ⓘ |
| inhibits | complement cascade on host cells ⓘ |
| involvedIn |
T cell activation regulation
ⓘ
Th1 to Th2 switching ⓘ |
| locatedIn |
cell surface
ⓘ
plasma membrane ⓘ |
| memberOf | regulators of complement activation gene cluster ⓘ |
| participatesIn |
adaptive immune response modulation
ⓘ
innate immune response ⓘ |
| prevents | complement-mediated autologous cell lysis ⓘ |
| usedIn | oncolytic measles virus targeting strategies ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CD46 Description of subject: CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
human adenovirus serotype 26 (Ad26)
linked to: CD46