VKORC1
E852347
VKORC1 is an enzyme involved in vitamin K recycling that plays a key role in blood clotting and is the primary molecular target of the anticoagulant drug warfarin.
All labels observed (5)
How this entity was disambiguated
This entity first appeared as the object of triple T10291960 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: VKORC1 Context triple: [warfarin, targets, VKORC1]
-
A.
CYP2C9
CYP2C9 is a liver enzyme of the cytochrome P450 family that plays a key role in metabolizing various drugs, including many nonsteroidal anti-inflammatory agents and anticoagulants.
-
B.
CYP2C19
CYP2C19 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs, including certain antidepressants, proton pump inhibitors, and antiplatelet agents.
-
C.
warfarin
Warfarin is a long-established oral anticoagulant used to prevent and treat blood clots, requiring regular blood monitoring and dose adjustments due to its narrow therapeutic range and numerous drug and food interactions.
-
D.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
E.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: VKORC1 Target entity description: VKORC1 is an enzyme involved in vitamin K recycling that plays a key role in blood clotting and is the primary molecular target of the anticoagulant drug warfarin.
-
A.
CYP2C9
CYP2C9 is a liver enzyme of the cytochrome P450 family that plays a key role in metabolizing various drugs, including many nonsteroidal anti-inflammatory agents and anticoagulants.
-
B.
CYP2C19
CYP2C19 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs, including certain antidepressants, proton pump inhibitors, and antiplatelet agents.
-
C.
warfarin
Warfarin is a long-established oral anticoagulant used to prevent and treat blood clots, requiring regular blood monitoring and dose adjustments due to its narrow therapeutic range and numerous drug and food interactions.
-
D.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
E.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
enzyme
ⓘ
protein-coding gene ⓘ |
| associatedWith |
anticoagulant sensitivity
ⓘ
bleeding risk under warfarin therapy ⓘ warfarin dose variability ⓘ |
| biologicalProcess |
blood coagulation
ⓘ
gamma-carboxylation of glutamate residues ⓘ vitamin K cycle ⓘ |
| cellularComponent | endoplasmic reticulum membrane ⓘ |
| chromosomalBand | 16p11.2 ⓘ |
| clinicalUse | pharmacogenetic marker for warfarin dosing ⓘ |
| diseaseAssociation |
vitamin K–dependent clotting factor deficiency type 2 (VKCFD2)
ⓘ
warfarin resistance ⓘ |
| encodes |
vitamin K epoxide reductase complex subunit 1 protein
ⓘ
linked to:
VKORC1
|
| enzymeCommissionNumber | EC 1.17.4.4 ⓘ |
| expression |
liver
ⓘ
vascular tissues ⓘ |
| fullName |
vitamin K epoxide reductase complex subunit 1
ⓘ
linked to:
VKORC1
|
| geneID |
VKORC1 (HGNC:12621)
ⓘ
linked to:
VKORC1
|
| inheritanceOfDeficiency | autosomal recessive ⓘ |
| locatedOnChromosome | human chromosome 16 ⓘ |
| molecularFunction |
oxidoreductase activity
ⓘ
vitamin K epoxide reductase (warfarin-sensitive) ⓘ
linked to:
VKORC1
|
| orthologIn |
Bos taurus
ⓘ
Mus musculus ⓘ
linked to:
house mouse (Mus musculus)
Rattus norvegicus ⓘ
linked to:
Norway rat (Rattus norvegicus)
|
| pathway |
vitamin K-dependent clotting factor activation pathway
ⓘ
warfarin pharmacodynamics pathway ⓘ |
| polymorphism |
-1639G>A (c.-1639G>A)
ⓘ
1173C>T (c.1173C>T intronic variant) ⓘ rs9923231 ⓘ
linked to:
dbSNP
rs9934438 ⓘ
linked to:
dbSNP
|
| polymorphismEffect |
alters VKORC1 expression
ⓘ
modulates warfarin dose requirement ⓘ |
| product | vitamin K hydroquinone ⓘ |
| requiredForActivationOf |
coagulation factor IX
ⓘ
coagulation factor VII ⓘ coagulation factor X ⓘ protein C ⓘ protein S ⓘ protein Z ⓘ prothrombin (factor II) ⓘ |
| substrate | vitamin K epoxide ⓘ |
| targetOf |
acenocoumarol
ⓘ
coumarin anticoagulants ⓘ phenprocoumon ⓘ
linked to:
warfarin
warfarin ⓘ |
| topology | multi-pass membrane protein ⓘ |
| uniprotID | Q9BQB6 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: VKORC1 Description of subject: VKORC1 is an enzyme involved in vitamin K recycling that plays a key role in blood clotting and is the primary molecular target of the anticoagulant drug warfarin.
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: VKORC1