folinic acid (leucovorin)
E822405
Folinic acid (leucovorin) is a reduced form of folic acid used clinically to enhance the effects of certain chemotherapy drugs like fluorouracil and to "rescue" normal cells from the toxic effects of folate antagonists such as methotrexate.
All labels observed (5)
| Label | Occurrences |
|---|---|
| Calcium Folinate | 1 |
| Leucovorin | 1 |
| calcium folinate | 1 |
| folinic acid (leucovorin) canonical | 1 |
| leucovorin | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T9807204 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: folinic acid (leucovorin) Context triple: [Xeloda, interactsWith, folinic acid (leucovorin)]
-
A.
Flavin
Flavin is a surname most notably associated with American minimalist artist Dan Flavin, renowned for his fluorescent light installations.
-
B.
B12
B12 is the common shorthand used to refer to the Big 12 Conference, a major collegiate athletic conference in the United States.
-
C.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
-
D.
Fenodyree
Fenodyree is a mythical, goblin-like creature from Alan Garner’s fantasy novel "The Weirdstone of Brisingamen," known for aiding the protagonists with its otherworldly powers and knowledge of the hidden realms.
-
E.
methotrexate
Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly used to treat autoimmune conditions such as rheumatoid arthritis, psoriasis, and certain cancers by inhibiting folate-dependent cell proliferation.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: folinic acid (leucovorin) Target entity description: Folinic acid (leucovorin) is a reduced form of folic acid used clinically to enhance the effects of certain chemotherapy drugs like fluorouracil and to "rescue" normal cells from the toxic effects of folate antagonists such as methotrexate.
-
A.
Flavin
Flavin is a surname most notably associated with American minimalist artist Dan Flavin, renowned for his fluorescent light installations.
-
B.
B12
B12 is the common shorthand used to refer to the Big 12 Conference, a major collegiate athletic conference in the United States.
-
C.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
-
D.
Fenodyree
Fenodyree is a mythical, goblin-like creature from Alan Garner’s fantasy novel "The Weirdstone of Brisingamen," known for aiding the protagonists with its otherworldly powers and knowledge of the hidden realms.
-
E.
methotrexate
Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly used to treat autoimmune conditions such as rheumatoid arthritis, psoriasis, and certain cancers by inhibiting folate-dependent cell proliferation.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
antidote
ⓘ
antineoplastic adjunct ⓘ chemical compound ⓘ pharmaceutical drug ⓘ vitamin B9 derivative ⓘ |
| activeIsomer | L-folinic acid ⓘ |
| antidoteFor |
methotrexate
ⓘ
pyrimethamine ⓘ trimethoprim ⓘ |
| belongsTo | folate analogs ⓘ |
| bypassesInhibitionOf | dihydrofolate reductase ⓘ |
| commonAdverseEffect |
allergic reactions
ⓘ
diarrhea ⓘ nausea ⓘ vomiting ⓘ |
| doesNotRequire | dihydrofolate reductase for activation ⓘ |
| enhancesEffectOf | fluorouracil ⓘ |
| hasATCCode |
L01BA04
ⓘ
V03AF03 ⓘ |
| hasChemicalFormula | C20H23N7O7 ⓘ |
| hasMolarMass | 473.44 g/mol ⓘ |
| hasPregnancyCategory | generally considered low risk when clinically indicated ⓘ |
| hasRouteOfAdministration |
intramuscular
ⓘ
intravenous ⓘ oral ⓘ |
| hasSynonym |
5-formyl-THF
ⓘ
5-formyltetrahydrofolate ⓘ calcium folinate ⓘ
linked to:
folinic acid (leucovorin)
citrovorum factor ⓘ leucovorin ⓘ
linked to:
folinic acid (leucovorin)
leucovorin calcium ⓘ |
| isEnantiomerMixture | racemic mixture of D- and L-forms ⓘ |
| isFormOf | tetrahydrofolate ⓘ |
| isMarketedAs |
Calcium Folinate
ⓘ
linked to:
folinic acid (leucovorin)
Leucovorin ⓘ
linked to:
folinic acid (leucovorin)
Wellcovorin ⓘ |
| isOn | World Health Organization Model List of Essential Medicines ⓘ |
| isReducedFormOf | folic acid ⓘ |
| mayReduceEffectOf | antiepileptic drugs such as phenobarbital, phenytoin, primidone ⓘ |
| mechanismOfAction | stabilizes binding of fluorodeoxyuridylate to thymidylate synthase ⓘ |
| protects | normal cells from high-dose methotrexate toxicity ⓘ |
| usedFor |
advanced colorectal carcinoma
ⓘ
colorectal cancer ⓘ megaloblastic anemia due to folate deficiency when oral therapy not feasible ⓘ methotrexate toxicity rescue ⓘ osteosarcoma regimens with high-dose methotrexate ⓘ overdose of folate antagonists ⓘ palliative treatment of colorectal cancer ⓘ prevention of methotrexate-induced mucositis ⓘ |
| usedWith | fluorouracil ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: folinic acid (leucovorin) Description of subject: Folinic acid (leucovorin) is a reduced form of folic acid used clinically to enhance the effects of certain chemotherapy drugs like fluorouracil and to "rescue" normal cells from the toxic effects of folate antagonists such as methotrexate.
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
folinic acid (leucovorin)
linked to: folinic acid (leucovorin)
subject linked to:
folinic acid (leucovorin)
linked to: folinic acid (leucovorin)
subject linked to:
folinic acid (leucovorin)
linked to: folinic acid (leucovorin)
subject linked to:
folinic acid (leucovorin)
linked to: folinic acid (leucovorin)