CD3 complex
E802043
The CD3 complex is a multi-subunit protein complex associated with the T-cell receptor that is essential for T-cell activation and signal transduction in the immune system.
All labels observed (4)
| Label | Occurrences |
|---|---|
| CD3 | 2 |
| CD3 complex canonical | 1 |
| CD3γ chain | 1 |
| T-cell receptor–CD3 complex | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T9477924 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CD3 complex Context triple: [CD4+ T cells, express, CD3 complex]
-
A.
CD20 protein
CD20 protein is a cell-surface antigen found primarily on B lymphocytes and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
-
B.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
-
C.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
-
D.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
-
E.
CD4+ T cells
CD4+ T cells are a subset of immune cells that coordinate and regulate the body’s adaptive immune response, playing a central role in defending against infections.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CD3 complex Target entity description: The CD3 complex is a multi-subunit protein complex associated with the T-cell receptor that is essential for T-cell activation and signal transduction in the immune system.
-
A.
CD20 protein
CD20 protein is a cell-surface antigen found primarily on B lymphocytes and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
-
B.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
-
C.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
-
D.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
-
E.
CD4+ T cells
CD4+ T cells are a subset of immune cells that coordinate and regulate the body’s adaptive immune response, playing a central role in defending against infections.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
T-cell surface receptor component
ⓘ
protein complex ⓘ |
| abbreviatedAs |
CD3
ⓘ
linked to:
CD3 complex
|
| associatedWith | T-cell receptor ⓘ |
| associatedWithDisease |
T-cell immunodeficiency
ⓘ
severe combined immunodeficiency when mutated ⓘ |
| binds |
T-cell receptor alpha chain
ⓘ
T-cell receptor beta chain ⓘ |
| containsMotif | immunoreceptor tyrosine-based activation motif ⓘ |
| encodedBy |
CD247 gene
ⓘ
CD3D gene ⓘ CD3E gene ⓘ CD3G gene ⓘ |
| essentialFor |
T-cell activation
ⓘ
T-cell signal transduction ⓘ |
| expressedOn |
mature T cells
ⓘ
most NKT cells ⓘ thymocytes ⓘ |
| hasComponentType | type I transmembrane protein ⓘ |
| hasCytoplasmicDomainFunction | signal transduction ⓘ |
| hasSubunit |
CD3γ chain
ⓘ
linked to:
CD3 complex
CD3δ chain ⓘ CD3ε chain ⓘ
linked to:
CD3E gene
CD3ζ chain ⓘ CD3η chain ⓘ |
| hasTopology |
cytoplasmic tail with ITAMs
ⓘ
extracellular immunoglobulin-like domain ⓘ single transmembrane helix ⓘ |
| involvedIn |
T-cell receptor signaling pathway
ⓘ
T-cell selection in thymus ⓘ adaptive immune response ⓘ thymocyte development ⓘ |
| locatedIn | plasma membrane of T cells ⓘ |
| orthologFoundIn |
human
ⓘ
mouse ⓘ rat ⓘ |
| partOf |
T-cell receptor–CD3 complex
ⓘ
linked to:
CD3 complex
|
| phosphorylatedBy |
Src family kinases Lck and Fyn
ⓘ
linked to:
Src family kinases
|
| playsRoleIn |
T-cell proliferation
ⓘ
antigen-specific T-cell responses ⓘ cytokine production by T cells ⓘ |
| recognizedBy | anti-CD3 monoclonal antibodies ⓘ |
| recruits | ZAP-70 tyrosine kinase ⓘ |
| requiredFor |
T-cell receptor internalization
ⓘ
surface expression of T-cell receptor ⓘ |
| targetOf | OKT3 antibody ⓘ |
| usedAsMarkerFor | T lymphocytes ⓘ |
| usedIn |
flow cytometry for T-cell enumeration
ⓘ
immunohistochemistry for T-cell identification ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CD3 complex Description of subject: The CD3 complex is a multi-subunit protein complex associated with the T-cell receptor that is essential for T-cell activation and signal transduction in the immune system.
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: CD3 complex
linked to: CD3 complex
linked to: CD3 complex
subject linked to:
mosunetuzumab (bispecific antibody component)
linked to: CD3 complex