bacteriophage lambda

E629012

Bacteriophage lambda is a temperate virus that infects Escherichia coli and serves as a classic model system for studying gene regulation, lysogeny, and molecular genetics.

All labels observed (2)

How this entity was disambiguated

Statements (61)

Predicate Object
instanceOf Siphoviridae
double-stranded DNA virus
temperate bacteriophage
virus
belongsToFamily Siphoviridae
belongsToOrder Caudovirales
cosSiteLength 12 nucleotides
decisionProcess lysis-lysogeny switch
discoveredBy Esther Lederberg
discoveryYear 1950
encodes CI repressor
CII protein
CIII protein
Cro protein
Gam protein
Int integrase
N antiterminator protein
Q antiterminator protein
Red recombination proteins
Xis excisionase
head and tail structural proteins
genomeSize approximately 48.5 kilobase pairs
genomeType linear double-stranded DNA
hasCohesiveEnds cos sites
hasGCContent approximately 50 percent
hasLifeCycle lysogenic cycle
lytic cycle
hasMorphology icosahedral head with long noncontractile tail
hasOperator OL operator region
OR operator region
hasPackagingLimit approximately 52 kilobase pairs
hasRegulatoryRegion PL promoter
PR promoter
PRM promoter
host Escherichia coli K-12
linked to: Escherichia coli
inducedBy DNA damage
inductionMechanism SOS response mediated CI cleavage
infects Escherichia coli
integratesInto E. coli chromosome
integrationSite attB site in E. coli
between gal and bio operons in E. coli
isTemperate true
keyRegulator CI repressor
Cro protein
keyRegulator CII protein
N protein
Q protein
prophageForm integrated into host chromosome
repressorMaintains prophage state
requiresForIntegration host IHF protein
requiresForReplication host DNA replication machinery
tailType long noncontractile tail
taxonRank species
usedAs cloning vector
phage display vector
usedAsModelFor developmental decision-making in phages
gene regulation
lysogeny
molecular genetics
site-specific recombination
transcriptional regulation

How these facts were elicited

Referenced by (3)

Full triples — surface form annotated when it differs from this entity's canonical label.

Gunther Stent researchSubject bacteriophage lambda
A Genetic Switch: Phage Lambda and Higher Organisms usesModelOrganism Escherichia coli bacteriophage lambda
linked to: bacteriophage lambda