FIREFISH
E561096
FIREFISH is a pivotal clinical trial evaluating the efficacy and safety of risdiplam in infants with Type 1 spinal muscular atrophy.
All labels observed (2)
| Label | Occurrences |
|---|---|
| FIREFISH canonical | 1 |
| FIREFISH Part 2 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6004783 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: FIREFISH Context triple: [risdiplam, clinicalTrialProgram, FIREFISH]
-
A.
Fishke
Fishke is the titular lame Jewish protagonist of Mendele Mocher Sforim’s classic Yiddish novel "Fishke the Lame," known for its blend of social critique and folk humor.
-
B.
Fysh
Fysh is a surname most notably associated with Sir Hudson Fysh, the Australian aviator and co-founder of Qantas.
-
C.
More Fish
More Fish is a 2006 hip-hop album by Wu-Tang Clan member Ghostface Killah that serves as a companion piece to his acclaimed album Fishscale.
-
D.
Fishscale
Fishscale is a critically acclaimed 2006 hip-hop album by Wu-Tang Clan member Ghostface Killah, known for its vivid street narratives and soulful, sample-heavy production.
-
E.
Ichthyas
Ichthyas was an ancient Greek philosopher associated with the Megarian school, known for his work in logic and dialectical argument.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: FIREFISH Target entity description: FIREFISH is a pivotal clinical trial evaluating the efficacy and safety of risdiplam in infants with Type 1 spinal muscular atrophy.
-
A.
Fishke
Fishke is the titular lame Jewish protagonist of Mendele Mocher Sforim’s classic Yiddish novel "Fishke the Lame," known for its blend of social critique and folk humor.
-
B.
Fysh
Fysh is a surname most notably associated with Sir Hudson Fysh, the Australian aviator and co-founder of Qantas.
-
C.
More Fish
More Fish is a 2006 hip-hop album by Wu-Tang Clan member Ghostface Killah that serves as a companion piece to his acclaimed album Fishscale.
-
D.
Fishscale
Fishscale is a critically acclaimed 2006 hip-hop album by Wu-Tang Clan member Ghostface Killah, known for its vivid street narratives and soulful, sample-heavy production.
-
E.
Ichthyas
Ichthyas was an ancient Greek philosopher associated with the Megarian school, known for his work in logic and dialectical argument.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
clinical trial
ⓘ
confirmatory efficacy and safety study ⓘ dose-finding study ⓘ pivotal trial ⓘ |
| assessesOutcomeMeasure |
Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders
ⓘ
Hammersmith Infant Neurological Examination Section 2 ⓘ overall survival ⓘ ventilation-free survival ⓘ |
| developedWith |
PTC Therapeutics
ⓘ
SMA Foundation ⓘ |
| enrollsAgeGroup | infants aged 1 to 7 months at first dose ⓘ |
| evaluates | risdiplam ⓘ |
| hasCondition | 5q-associated spinal muscular atrophy Type 1 ⓘ |
| hasDesign |
multicenter
ⓘ
open-label ⓘ two-part study ⓘ |
| hasGeographicScope | international ⓘ |
| hasInterventionModel | single-group assignment ⓘ |
| hasObjective | determine the dose of risdiplam for Part 2 ⓘ |
| hasOutcome |
demonstrated clinically meaningful motor function improvement
ⓘ
demonstrated survival benefit compared with natural history ⓘ |
| hasPart |
FIREFISH Part 1
ⓘ
FIREFISH Part 2 ⓘ
linked to:
FIREFISH
|
| hasPhase | Phase 2 ⓘ |
| hasPopulation | infants with Type 1 spinal muscular atrophy ⓘ |
| hasPrimaryEndpoint |
proportion of infants sitting without support
ⓘ
survival without permanent ventilation ⓘ |
| hasPrimaryObjective | evaluate efficacy of risdiplam in infants with Type 1 spinal muscular atrophy ⓘ |
| hasPublicationType | peer-reviewed clinical trial report ⓘ |
| hasSecondaryObjective | evaluate safety of risdiplam in infants with Type 1 spinal muscular atrophy ⓘ |
| hasTherapeuticArea |
neuromuscular disease
ⓘ
rare disease ⓘ |
| investigatesIndication |
Type 1 spinal muscular atrophy
ⓘ
linked to:
spinal muscular atrophy
infantile-onset spinal muscular atrophy ⓘ |
| monitorsSafetyParameters |
adverse events
ⓘ
laboratory abnormalities ⓘ ophthalmologic findings ⓘ |
| relatedTo |
JEWELFISH clinical trial
ⓘ
RAINBOWFISH clinical trial ⓘ SUNFISH clinical trial ⓘ |
| sponsor |
F. Hoffmann-La Roche Ltd
ⓘ
linked to:
Roche
Roche ⓘ |
| studiesDrug | risdiplam ⓘ |
| supportsRegulatoryDecision | approval of risdiplam for treatment of spinal muscular atrophy ⓘ |
| targetsPathology | survival motor neuron protein deficiency ⓘ |
| usesDrugMechanism | SMN2 pre-mRNA splicing modification by risdiplam ⓘ |
| usesRouteOfAdministration | oral administration of risdiplam ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: FIREFISH Description of subject: FIREFISH is a pivotal clinical trial evaluating the efficacy and safety of risdiplam in infants with Type 1 spinal muscular atrophy.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.