Truvada
E409694
Truvada is a prescription antiretroviral medication widely used both to treat HIV infection and as pre-exposure prophylaxis (PrEP) to help prevent HIV in high-risk individuals.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Truvada canonical | 1 |
| emtricitabine and tenofovir disoproxil fumarate | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4050927 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Truvada Context triple: [Gilead Sciences, product, Truvada]
-
A.
AZT
AZT is the standard time zone used in Azerbaijan, typically four hours ahead of Coordinated Universal Time (UTC+4).
-
B.
Waylivra
Waylivra is a prescription antisense oligonucleotide therapy used to treat familial chylomicronemia syndrome (FCS) by reducing triglyceride levels in the blood.
-
C.
Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
-
D.
Darzalex
Darzalex is a monoclonal antibody drug (daratumumab) used primarily in the treatment of multiple myeloma.
-
E.
Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Truvada Target entity description: Truvada is a prescription antiretroviral medication widely used both to treat HIV infection and as pre-exposure prophylaxis (PrEP) to help prevent HIV in high-risk individuals.
-
A.
AZT
AZT is the standard time zone used in Azerbaijan, typically four hours ahead of Coordinated Universal Time (UTC+4).
-
B.
Waylivra
Waylivra is a prescription antisense oligonucleotide therapy used to treat familial chylomicronemia syndrome (FCS) by reducing triglyceride levels in the blood.
-
C.
Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
-
D.
Darzalex
Darzalex is a monoclonal antibody drug (daratumumab) used primarily in the treatment of multiple myeloma.
-
E.
Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
HIV medication
ⓘ
antiretroviral medication ⓘ brand-name drug ⓘ fixed-dose combination drug ⓘ |
| approvedBy |
Food and Drug Administration
ⓘ
surface form:
U.S. Food and Drug Administration
|
| ATCCode | J05AR02 ⓘ |
| boxedWarning |
risk of acute exacerbations of hepatitis B after discontinuation
ⓘ
risk of lactic acidosis and severe hepatomegaly with steatosis ⓘ |
| commonSideEffect |
diarrhea
ⓘ
headache ⓘ nausea ⓘ |
| containsDoseStrength |
emtricitabine 200 mg
ⓘ
tenofovir disoproxil fumarate 300 mg ⓘ |
| contraindication | severe renal impairment ⓘ |
| developer |
Gilead Sciences (board member)
ⓘ
surface form:
Gilead Sciences
|
| dosageForm | tablet ⓘ |
| drugClass |
nucleoside reverse transcriptase inhibitor
ⓘ
nucleotide reverse transcriptase inhibitor ⓘ |
| FDAApprovalIndication |
pre-exposure prophylaxis to reduce the risk of sexually acquired HIV-1 infection
ⓘ
treatment of HIV-1 infection in combination with other antiretrovirals ⓘ |
| FDAApprovalYear | 2004 ⓘ |
| hasActiveIngredient |
emtricitabine
ⓘ
tenofovir disoproxil fumarate ⓘ |
| hasGenericName |
Truvada
self-linksurface differs
ⓘ
surface form:
emtricitabine and tenofovir disoproxil fumarate
|
| hasPatentHolder |
Gilead Sciences (board member)
ⓘ
surface form:
Gilead Sciences
|
| indication |
post-exposure prophylaxis for HIV (off-label in some settings)
ⓘ
pre-exposure prophylaxis for HIV-1 (PrEP) ⓘ treatment of HIV-1 infection ⓘ |
| isGenericAvailable | true ⓘ |
| isNotEffectiveAgainst | established HIV infection when used alone ⓘ |
| isOnWHOEML | yes ⓘ |
| isUsedWith | other antiretroviral agents ⓘ |
| legalStatusEU | prescription-only ⓘ |
| legalStatusUS | prescription-only ⓘ |
| marketingAuthorizationHolder |
Gilead Sciences (board member)
ⓘ
surface form:
Gilead Sciences
|
| pregnancyCategoryUS | B (historical classification) ⓘ |
| prevents | sexual transmission of HIV-1 when used as PrEP with adherence ⓘ |
| requiresCombinationForTreatment | yes ⓘ |
| requiresMonitoring |
HIV status before and during PrEP
ⓘ
renal function ⓘ |
| routeOfAdministration | oral ⓘ |
| seriousSideEffect |
decreased bone mineral density
ⓘ
renal impairment ⓘ |
| takenFrequency | once daily ⓘ |
| targets |
HIV-1
ⓘ
surface form:
HIV-1 reverse transcriptase
|
| usedForPopulation |
adolescents at high risk of HIV infection (meeting weight and other criteria)
ⓘ
adults at high risk of HIV infection ⓘ |
| usedInProgram | HIV prevention programs worldwide ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Truvada Description of subject: Truvada is a prescription antiretroviral medication widely used both to treat HIV infection and as pre-exposure prophylaxis (PrEP) to help prevent HIV in high-risk individuals.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Gilead Sciences
this entity surface form:
emtricitabine and tenofovir disoproxil fumarate