click chemistry
E316989
Click chemistry is a modular, high-yielding approach to chemical synthesis that uses simple, reliable reactions to rapidly assemble complex molecules, widely applied in drug discovery, materials science, and chemical biology.
All labels observed (2)
| Label | Occurrences |
|---|---|
| click chemistry canonical | 2 |
| CuAAC | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2974283 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: click chemistry Context triple: [K. Barry Sharpless, notableWork, click chemistry]
-
A.
ChemCatChem
ChemCatChem is a peer-reviewed scientific journal focusing on catalysis research, including homogeneous, heterogeneous, and biocatalysis, published by Wiley-VCH.
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B.
ChemMedChem
ChemMedChem is a peer-reviewed scientific journal focusing on medicinal chemistry and related interdisciplinary drug research.
-
C.
The Logic of Chemical Synthesis
The Logic of Chemical Synthesis is a seminal book by chemist Elias J. Corey that systematically presents the principles and strategies of retrosynthetic analysis for designing complex organic molecule syntheses.
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D.
ChemSusChem
ChemSusChem is a peer-reviewed scientific journal focusing on research in sustainable chemistry and energy published by Wiley-VCH.
-
E.
CAS Common Chemistry
CAS Common Chemistry is a free online resource from the Chemical Abstracts Service that provides curated chemical information, including identifiers and basic data for commonly encountered substances.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: click chemistry Target entity description: Click chemistry is a modular, high-yielding approach to chemical synthesis that uses simple, reliable reactions to rapidly assemble complex molecules, widely applied in drug discovery, materials science, and chemical biology.
-
A.
ChemCatChem
ChemCatChem is a peer-reviewed scientific journal focusing on catalysis research, including homogeneous, heterogeneous, and biocatalysis, published by Wiley-VCH.
-
B.
ChemMedChem
ChemMedChem is a peer-reviewed scientific journal focusing on medicinal chemistry and related interdisciplinary drug research.
-
C.
The Logic of Chemical Synthesis
The Logic of Chemical Synthesis is a seminal book by chemist Elias J. Corey that systematically presents the principles and strategies of retrosynthetic analysis for designing complex organic molecule syntheses.
-
D.
ChemSusChem
ChemSusChem is a peer-reviewed scientific journal focusing on research in sustainable chemistry and energy published by Wiley-VCH.
-
E.
CAS Common Chemistry
CAS Common Chemistry is a free online resource from the Chemical Abstracts Service that provides curated chemical information, including identifiers and basic data for commonly encountered substances.
- F. None of above. chosen
Statements (52)
| Predicate | Object |
|---|---|
| instanceOf |
chemical concept
ⓘ
modular synthesis strategy ⓘ synthetic methodology ⓘ |
| characteristic |
fast reaction kinetics
ⓘ
high selectivity ⓘ high-yielding reactions ⓘ modular assembly of molecules ⓘ operational simplicity ⓘ orthogonality to many functional groups ⓘ produces inoffensive byproducts ⓘ reliability ⓘ tolerance of aqueous conditions ⓘ |
| coreReactionType |
click chemistry
self-linksurface differs
ⓘ
surface form:
CuAAC
Diels–Alder reaction ⓘ SPAAC ⓘ SuFEx ⓘ copper-catalyzed azide–alkyne cycloaddition ⓘ inverse electron-demand Diels–Alder reaction ⓘ strain-promoted azide–alkyne cycloaddition ⓘ sulfur(VI) fluoride exchange ⓘ thiol–ene reaction ⓘ thiol–yne reaction ⓘ |
| criterion |
high thermodynamic driving force
ⓘ
insensitivity to oxygen and water when possible ⓘ simple product isolation ⓘ use of readily available starting materials ⓘ |
| definedBy |
Hartmuth C. Kolb
NERFINISHED
ⓘ
K. Barry Sharpless ⓘ M. G. Finn ⓘ |
| enables | bioorthogonal labeling in living systems ⓘ |
| fieldOfApplication |
bioconjugation
ⓘ
chemical biology ⓘ drug discovery ⓘ materials science ⓘ medicinal chemistry ⓘ nanotechnology ⓘ polymer chemistry ⓘ |
| goal |
rapid assembly of complex molecules
ⓘ
streamlining chemical synthesis ⓘ |
| hasSubfield | bioorthogonal click chemistry ⓘ |
| introducedInPublication |
Angewandte Chemie
ⓘ
surface form:
Angewandte Chemie International Edition
|
| introducedInYear | 2001 ⓘ |
| recognizedBy | Royal Swedish Academy of Sciences ⓘ |
| relatedAward |
Nobel Prize in Chemistry
ⓘ
surface form:
2022 Nobel Prize in Chemistry
|
| usedFor |
antibody–drug conjugate construction
ⓘ
biomolecule labeling ⓘ combinatorial library synthesis ⓘ fragment-based drug design ⓘ in vivo imaging ⓘ polymer functionalization ⓘ surface modification ⓘ target identification in chemical biology ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: click chemistry Description of subject: Click chemistry is a modular, high-yielding approach to chemical synthesis that uses simple, reliable reactions to rapidly assemble complex molecules, widely applied in drug discovery, materials science, and chemical biology.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
CuAAC