DEAD-box helicase 20

Target entity: DEAD-box helicase 20
Context triple: [Gemin3, hasAlternativeName, DEAD-box helicase 20]

• A. TARDBP
  TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
• B. U1 snRNP
  U1 snRNP is a small nuclear ribonucleoprotein complex essential for recognizing the 5′ splice site and initiating pre-mRNA splicing in eukaryotic cells.
• C. FOXA2 transcription factor
  FOXA2 transcription factor is a forkhead box transcription factor that plays a key role in regulating genes involved in pancreatic beta-cell function, glucose metabolism, and endoderm development.
• D. Cdh1
  Cdh1 is a regulatory protein that activates the anaphase-promoting complex/cyclosome (APC/C) to control mitotic exit and G1 phase progression in the cell cycle.
• E. TATA-box binding protein associated factor 15
  TATA-box binding protein associated factor 15 (TAF15) is an RNA- and DNA-binding protein of the FET family involved in transcriptional regulation and RNA processing, and is implicated in certain cancers through gene fusions.
• F. None of above. chosen
• G. Unsure - the case is ambiguous/there is not enough information to decide.

Target entity: DEAD-box helicase 20
Target entity description: DEAD-box helicase 20 is an ATP-dependent RNA helicase involved in RNA processing and ribonucleoprotein complex assembly, encoded by the human DDX20 gene.

• A. TARDBP
  TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
• B. U2 snRNP
  U2 snRNP is a small nuclear ribonucleoprotein complex that recognizes the branch point sequence in pre-mRNA and plays a key role in spliceosome-mediated RNA splicing.
• C. U1 snRNP
  U1 snRNP is a small nuclear ribonucleoprotein complex essential for recognizing the 5′ splice site and initiating pre-mRNA splicing in eukaryotic cells.
• D. FOXA2 transcription factor
  FOXA2 transcription factor is a forkhead box transcription factor that plays a key role in regulating genes involved in pancreatic beta-cell function, glucose metabolism, and endoderm development.
• E. Cdh1
  Cdh1 is a regulatory protein that activates the anaphase-promoting complex/cyclosome (APC/C) to control mitotic exit and G1 phase progression in the cell cycle.
• F. None of above. chosen