PIKfyve
E1551032
UNEXPLORED
PIKfyve is a lipid kinase that synthesizes phosphatidylinositol 3,5-bisphosphate and plays a key role in endosomal trafficking and lysosomal function.
All labels observed (1)
| Label | Occurrences |
|---|---|
| PIKfyve canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T22693141 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: PIKfyve Context triple: [WDR41, binds, PIKfyve]
-
A.
NPC1L1 transporter
The NPC1L1 transporter is an intestinal membrane protein that mediates cholesterol absorption from the gut and is inhibited by the lipid-lowering drug ezetimibe.
-
B.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
C.
Ezrin
Ezrin is a Canadian music producer and songwriter best known for his work on landmark rock albums by artists such as Pink Floyd, Alice Cooper, and Kiss.
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D.
LDL receptor
The LDL receptor is a cell-surface protein that binds and internalizes low-density lipoprotein particles, playing a central role in cholesterol homeostasis and cardiovascular disease risk.
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E.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: PIKfyve Target entity description: PIKfyve is a lipid kinase that synthesizes phosphatidylinositol 3,5-bisphosphate and plays a key role in endosomal trafficking and lysosomal function.
-
A.
NPC1L1 transporter
The NPC1L1 transporter is an intestinal membrane protein that mediates cholesterol absorption from the gut and is inhibited by the lipid-lowering drug ezetimibe.
-
B.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
C.
Ezrin
Ezrin is a Canadian music producer and songwriter best known for his work on landmark rock albums by artists such as Pink Floyd, Alice Cooper, and Kiss.
-
D.
LDL receptor
The LDL receptor is a cell-surface protein that binds and internalizes low-density lipoprotein particles, playing a central role in cholesterol homeostasis and cardiovascular disease risk.
-
E.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.