mu-opioid receptor
E1412779
UNEXPLORED
The mu-opioid receptor is a G protein–coupled receptor in the nervous system that mediates the powerful analgesic and euphoric effects of opioids as well as their major side effects, including respiratory depression and dependence.
All labels observed (1)
| Label | Occurrences |
|---|---|
| mu-opioid receptor canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T20125693 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: mu-opioid receptor Context triple: [Fentanyl, actsOnReceptor, mu-opioid receptor]
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A.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
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B.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
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C.
M2 muscarinic acetylcholine receptor
The M2 muscarinic acetylcholine receptor is a G protein–coupled receptor subtype primarily found in the heart, where it mediates parasympathetic (vagal) effects such as slowing heart rate and reducing contractility.
-
D.
somatostatin receptor
A somatostatin receptor is a G protein–coupled membrane receptor that binds the peptide hormone somatostatin to inhibit hormone secretion and modulate neurotransmission and cell proliferation.
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E.
NMDA receptor
The NMDA receptor is a glutamate-activated ion channel in the brain that plays a key role in synaptic plasticity, learning, and memory, and is implicated in various neurological and psychiatric disorders.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: mu-opioid receptor Target entity description: The mu-opioid receptor is a G protein–coupled receptor in the nervous system that mediates the powerful analgesic and euphoric effects of opioids as well as their major side effects, including respiratory depression and dependence.
-
A.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
B.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
C.
M2 muscarinic acetylcholine receptor
The M2 muscarinic acetylcholine receptor is a G protein–coupled receptor subtype primarily found in the heart, where it mediates parasympathetic (vagal) effects such as slowing heart rate and reducing contractility.
-
D.
somatostatin receptor
A somatostatin receptor is a G protein–coupled membrane receptor that binds the peptide hormone somatostatin to inhibit hormone secretion and modulate neurotransmission and cell proliferation.
-
E.
NMDA receptor
The NMDA receptor is a glutamate-activated ion channel in the brain that plays a key role in synaptic plasticity, learning, and memory, and is implicated in various neurological and psychiatric disorders.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.