ADAM-family metalloprotease
E1342624
UNEXPLORED
ADAM-family metalloproteases are membrane-anchored enzymes that cleave and activate various cell-surface proteins, playing key roles in processes such as cell signaling, development, and inflammation.
All labels observed (2)
| Label | Occurrences |
|---|---|
| ADAM-family metalloprotease canonical | 1 |
| ADAM17 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T18784284 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: ADAM-family metalloprotease Context triple: [Notch, requiresProcessingBy, ADAM-family metalloprotease]
-
A.
MT1-MMP (via BT1718)
MT1-MMP (via BT1718) is a membrane-bound matrix metalloproteinase exploited by the Bicycle Therapeutics drug candidate BT1718 as a tumor-targeting antigen for selective delivery of cytotoxic payloads to cancer cells.
-
B.
ase
"ase" is the ISO 639-3 language code assigned to American Sign Language, the primary sign language used by Deaf communities in the United States and parts of Canada.
-
C.
Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
-
D.
Serpins
Serpins is a civil parish in the municipality of Lousã in central Portugal, known for its natural landscapes and proximity to the Serra da Lousã.
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E.
ACE2
ACE2 is a human cell-surface enzyme and receptor that plays a key role in regulating blood pressure and serves as the primary entry point for SARS-CoV-2 into host cells.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: ADAM-family metalloprotease Target entity description: ADAM-family metalloproteases are membrane-anchored enzymes that cleave and activate various cell-surface proteins, playing key roles in processes such as cell signaling, development, and inflammation.
-
A.
MT1-MMP (via BT1718)
MT1-MMP (via BT1718) is a membrane-bound matrix metalloproteinase exploited by the Bicycle Therapeutics drug candidate BT1718 as a tumor-targeting antigen for selective delivery of cytotoxic payloads to cancer cells.
-
B.
ase
"ase" is the ISO 639-3 language code assigned to American Sign Language, the primary sign language used by Deaf communities in the United States and parts of Canada.
-
C.
Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
-
D.
Serpins
Serpins is a civil parish in the municipality of Lousã in central Portugal, known for its natural landscapes and proximity to the Serra da Lousã.
-
E.
ACE2
ACE2 is a human cell-surface enzyme and receptor that plays a key role in regulating blood pressure and serves as the primary entry point for SARS-CoV-2 into host cells.
- F. None of above. chosen
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: ADAM-family metalloprotease