Wegener's granulomatosis
E105929
Wegener's granulomatosis, now more commonly called granulomatosis with polyangiitis, is a rare autoimmune disease characterized by inflammation of blood vessels that can damage organs such as the lungs, kidneys, and upper respiratory tract.
All labels observed (7)
| Label | Occurrences |
|---|---|
| granulomatosis with polyangiitis | 3 |
| ANCA-associated vasculitis | 1 |
| Wegener | 1 |
| Wegener granulomatosis | 1 |
| Wegener vasculitis | 1 |
| Wegener's granulomatosis canonical | 1 |
| granulomatosis with polyangiitis (Wegener's) | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T891749 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Wegener's granulomatosis Context triple: [Heinrich Hertz, causeOfDeath, Wegener's granulomatosis]
-
A.
SLE
SLE is a mid-level trim package for GMC vehicles that typically adds upgraded comfort, convenience, and appearance features over the base model.
-
B.
Kerkinitis
Kerkinitis is an ancient Greek colony on the Crimean coast, later known as Eupatoria, that served as an important Black Sea trading settlement.
-
C.
Virchow's triad
Virchow's triad is a medical concept describing the three primary factors that contribute to the formation of blood clots: endothelial injury, abnormal blood flow, and hypercoagulability.
-
D.
Hodgkin
Hodgkin is a surname most famously associated with Dorothy Hodgkin, the Nobel Prize–winning British chemist who advanced the field of X-ray crystallography.
-
E.
Northgrippian
The Northgrippian is the middle age of the Holocene epoch, defined by a significant global cooling event that occurred around 4,200 years ago.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Wegener's granulomatosis Target entity description: Wegener's granulomatosis, now more commonly called granulomatosis with polyangiitis, is a rare autoimmune disease characterized by inflammation of blood vessels that can damage organs such as the lungs, kidneys, and upper respiratory tract.
-
A.
SLE
SLE is a mid-level trim package for GMC vehicles that typically adds upgraded comfort, convenience, and appearance features over the base model.
-
B.
Kerkinitis
Kerkinitis is an ancient Greek colony on the Crimean coast, later known as Eupatoria, that served as an important Black Sea trading settlement.
-
C.
Virchow's triad
Virchow's triad is a medical concept describing the three primary factors that contribute to the formation of blood clots: endothelial injury, abnormal blood flow, and hypercoagulability.
-
D.
Hodgkin
Hodgkin is a surname most famously associated with Dorothy Hodgkin, the Nobel Prize–winning British chemist who advanced the field of X-ray crystallography.
-
E.
Northgrippian
The Northgrippian is the middle age of the Holocene epoch, defined by a significant global cooling event that occurred around 4,200 years ago.
- F. None of above. chosen
Statements (65)
| Predicate | Object |
|---|---|
| instanceOf |
autoimmune disease
ⓘ
granulomatous disease ⓘ rare disease ⓘ systemic vasculitis ⓘ |
| affectsSystem |
lower respiratory tract
ⓘ
renal system ⓘ respiratory system ⓘ upper respiratory tract ⓘ vascular system ⓘ |
| associatedWithAntibody | anti-proteinase 3 antibody ⓘ |
| canCause |
chronic sinusitis
ⓘ
glomerulonephritis ⓘ hematuria ⓘ otitis media ⓘ proteinuria ⓘ pulmonary hemorrhage ⓘ pulmonary nodules ⓘ saddle-nose deformity ⓘ |
| hasAbbreviation | GPA ⓘ |
| hasBiomarker |
PR3-ANCA
ⓘ
c-ANCA ⓘ |
| hasClassification |
Wegener's granulomatosis
self-linksurface differs
ⓘ
surface form:
ANCA-associated vasculitis
small-vessel vasculitis ⓘ |
| hasCourse | chronic relapsing course ⓘ |
| hasDiagnosticTest |
ANCA test
ⓘ
chest CT scan ⓘ tissue biopsy ⓘ urinalysis ⓘ |
| hasEponym | Friedrich Wegener ⓘ |
| hasEtiology | autoimmune mechanism ⓘ |
| hasICD10Code | M31.3 ⓘ |
| hasPathologyFeature |
medium-vessel vasculitis
ⓘ
necrotizing granulomatous inflammation ⓘ necrotizing vasculitis ⓘ small-vessel vasculitis ⓘ |
| hasPreferredName |
Wegener's granulomatosis
self-linksurface differs
ⓘ
surface form:
granulomatosis with polyangiitis
|
| hasPrognosis | potentially life-threatening ⓘ |
| hasSymptom |
arthralgia
ⓘ
cough ⓘ dyspnea ⓘ epistaxis ⓘ fatigue ⓘ fever ⓘ hemoptysis ⓘ nasal congestion ⓘ weight loss ⓘ |
| hasSynonym |
Wegener's granulomatosis
self-linksurface differs
ⓘ
surface form:
Wegener granulomatosis
Wegener's granulomatosis self-linksurface differs ⓘ
surface form:
Wegener vasculitis
Wegener's granulomatosis self-linksurface differs ⓘ
surface form:
granulomatosis with polyangiitis (Wegener's)
|
| hasTreatmentPhase |
induction therapy
ⓘ
maintenance therapy ⓘ |
| moreCommonIn |
adults
ⓘ
middle-aged individuals ⓘ |
| recognizedBy |
American College of Rheumatology
ⓘ
Chapel Hill Consensus Conference on Vasculitis Nomenclature ⓘ |
| treatedWith |
azathioprine
ⓘ
cyclophosphamide ⓘ glucocorticoids ⓘ methotrexate ⓘ mycophenolate mofetil ⓘ Rituxan ⓘ
surface form:
rituximab
|
| typicalLesionSite |
kidneys
ⓘ
lungs ⓘ nasal cavity ⓘ paranasal sinuses ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Wegener's granulomatosis Description of subject: Wegener's granulomatosis, now more commonly called granulomatosis with polyangiitis, is a rare autoimmune disease characterized by inflammation of blood vessels that can damage organs such as the lungs, kidneys, and upper respiratory tract.
Referenced by (9)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
granulomatosis with polyangiitis
this entity surface form:
granulomatosis with polyangiitis (Wegener's)
this entity surface form:
Wegener granulomatosis
this entity surface form:
Wegener vasculitis
this entity surface form:
ANCA-associated vasculitis
this entity surface form:
granulomatosis with polyangiitis
this entity surface form:
granulomatosis with polyangiitis
this entity surface form:
Wegener