Disseminated intravascular coagulation
GPTKB entity
Statements (64)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
medical condition
hematologic disorder |
| gptkbp:abbreviation |
gptkb:DIC
|
| gptkbp:affects |
humans
|
| gptkbp:cause |
gptkb:liver_disease
gptkb:trauma death shock sepsis acute pancreatitis burns multi-organ failure snake bite malignancy hemolytic transfusion reaction placental abruption major surgery obstetric complications severe infection amniotic fluid embolism severe allergic reaction |
| gptkbp:complication |
sepsis
malignancy obstetric complications |
| gptkbp:field |
obstetrics
critical care medicine hematology |
| gptkbp:firstDescribed |
early 20th century
|
| gptkbp:has_laboratory_finding |
thrombocytopenia
elevated D-dimer low fibrinogen prolonged PT prolonged aPTT schistocytes on blood smear |
| gptkbp:has_mortality_rate |
high (varies by cause and severity)
|
| gptkbp:has_pathophysiology |
consumption of clotting factors
microvascular thrombosis secondary fibrinolysis widespread activation of coagulation cascade |
| https://www.w3.org/2000/01/rdf-schema#label |
Disseminated intravascular coagulation
|
| gptkbp:ICD-10_code |
gptkb:D65
|
| gptkbp:MeSH_ID |
D004221
|
| gptkbp:OMIM |
613244
|
| gptkbp:riskFactor |
gptkb:liver_disease
gptkb:trauma sepsis snake bite malignancy major surgery obstetric complications severe infection |
| gptkbp:symptom |
bleeding
thrombosis organ dysfunction bruising |
| gptkbp:treatment |
supportive care
treat underlying cause fresh frozen plasma cryoprecipitate blood product transfusion heparin (in selected cases) platelet transfusion |
| gptkbp:bfsParent |
gptkb:Schistocytes
|
| gptkbp:bfsLayer |
8
|