Digitoxin

GPTKB entity

Statements (42)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
cardiac glycoside
gptkbp:ATCCode C01AA04
gptkbp:CASNumber 71-63-6
gptkbp:category plant toxin
Glycoside
cardiotonic agent
steroid lactone
gptkbp:chemicalFormula C41H64O13
gptkbp:contraindication gptkb:ventricular_fibrillation
hypersensitivity to digitoxin
gptkbp:eliminationHalfLife 5–7 days
gptkbp:excretion renal
gptkbp:firstIsolatedFrom 1875
https://www.w3.org/2000/01/rdf-schema#label Digitoxin
gptkbp:IUPACName 3β-[O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]digitoxigenin
gptkbp:KEGGID D00294
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits Na+/K+-ATPase
gptkbp:meltingPoint 245–250 °C
gptkbp:metabolism hepatic
gptkbp:molecularWeight 764.94 g/mol
gptkbp:origin plant-derived
gptkbp:pregnancyCategory C (US)
gptkbp:PubChem_CID CHEMBL1409
2006931
2724385
DB01396
gptkbp:relatedTo gptkb:digoxin
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:arrhythmia
nausea
vomiting
visual disturbances
gptkbp:solubility very low
gptkbp:source gptkb:Digitalis_purpurea
gptkbp:toxicity narrow therapeutic index
gptkbp:UNII 73K4184T59
gptkbp:usedFor treatment of heart failure
treatment of atrial fibrillation
gptkbp:bfsParent gptkb:Glycoside
gptkbp:bfsLayer 7