Diabetes Mellitus, Type 1

URI: https://gptkb.org/entity/Diabetes_Mellitus,_Type_1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:disease
gptkbp:affects	pancreas endocrine system
gptkbp:affectsAllEthnicities	true
gptkbp:affectsBothGenders	true
gptkbp:alsoKnownAs	gptkb:Type_1_Diabetes Juvenile Diabetes
gptkbp:associatedWith	gptkb:HLA-DR4 HLA-DR3
gptkbp:canBeComplicatedBy	gptkb:cataracts atherosclerosis infections
gptkbp:cannotBePrevented	true
gptkbp:cause	gptkb:hypoglycemia hyperglycemia
gptkbp:causedBy	autoimmune destruction of pancreatic beta cells
gptkbp:complication	gptkb:cardiovascular_disease gptkb:diabetic_ketoacidosis gptkb:nephropathy peripheral neuropathy retinopathy
gptkbp:diagnosedBy	HbA1c test fasting blood glucose test autoantibody testing
gptkbp:firstDescribed	19th century
gptkbp:hasNoCure	true
https://www.w3.org/2000/01/rdf-schema#label	Diabetes Mellitus, Type 1
gptkbp:ICD-10_code	E10
gptkbp:incidenceIncreasing	true
gptkbp:managedBy	physical activity dietary management blood glucose monitoring
gptkbp:monitors	continuous glucose monitor fingerstick blood glucose test
gptkbp:notableContributor	gptkb:Frederick_Banting gptkb:Charles_Best
gptkbp:onset	childhood adolescence
gptkbp:prevalence	less common than Type 2 Diabetes
gptkbp:requiresLifelongTreatment	true
gptkbp:result	insulin deficiency
gptkbp:riskFactor	family history genetic predisposition environmental factors
gptkbp:symptom	fatigue weight loss polydipsia polyuria
gptkbp:treatment	insulin therapy
gptkbp:bfsParent	gptkb:D004053 gptkb:D003371 gptkb:D003700 gptkb:D004481
gptkbp:bfsLayer	7