DRACO (Double-stranded RNA Activated Caspase Oligomerizer)
GPTKB entity
Statements (18)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
antiviral therapeutic agent
|
| gptkbp:canBe |
broad-spectrum antiviral
|
| gptkbp:designedFor |
induce apoptosis in virus-infected cells
|
| gptkbp:developedBy |
gptkb:MIT
gptkb:Todd_Rider |
| gptkbp:firstDescribed |
2011
|
| gptkbp:fundedBy |
limited funding for further research
|
| https://www.w3.org/2000/01/rdf-schema#label |
DRACO (Double-stranded RNA Activated Caspase Oligomerizer)
|
| gptkbp:mechanismOfAction |
activates caspases
detects long double-stranded RNA triggers cell death in infected cells |
| gptkbp:notYetApprovedFor |
clinical use
|
| gptkbp:publishedIn |
PLoS ONE 2011 article by Rider et al.
|
| gptkbp:target |
viruses with double-stranded RNA intermediates
|
| gptkbp:testedBy |
mice
cell cultures |
| gptkbp:bfsParent |
gptkb:Todd_Rider
|
| gptkbp:bfsLayer |
8
|