gptkbp:instanceOf
|
gptkb:drug
|
gptkbp:approvalYear
|
2020
|
gptkbp:ATCCode
|
J05AB16
|
gptkbp:bioavailability
|
Low (prodrug, IV only)
|
gptkbp:brand
|
gptkb:Veklury
|
gptkbp:CASNumber
|
1809249-37-3
|
gptkbp:clinicalTrialPhase
|
Phase 3
|
gptkbp:contraindication
|
hypersensitivity to remdesivir
|
gptkbp:developer
|
gptkb:Gilead_Sciences
|
gptkbp:drugClass
|
antiviral drug
|
gptkbp:eliminationHalfLife
|
1 hour (remdesivir), 25 hours (GS-441524)
|
gptkbp:hasAdministrationForm
|
solution for infusion
|
gptkbp:hasApprovalCountry
|
gptkb:Australia
gptkb:Canada
gptkb:European_Union
gptkb:Japan
gptkb:United_States
|
gptkbp:hasBoxedWarning
|
nan
|
gptkbp:hasChemicalStructureType
|
antiviral drug
|
gptkbp:hasDrugBankAccessionNumber
|
gptkb:DB15054
|
gptkbp:hasInChIKey
|
RWWYLEGWBNMMLJ-YSOARWBDSA-N
|
gptkbp:hasMolecularFormula
|
C27H35N6O8P
|
gptkbp:hasPatentExpiry
|
2035
|
gptkbp:hasPatentHolder
|
gptkb:Gilead_Sciences
|
gptkbp:hasPharmacokinetics
|
Extensively metabolized to active nucleoside analog triphosphate
|
gptkbp:hasPregnancyWarning
|
Use only if potential benefit justifies risk
|
gptkbp:hasSMILES
|
CC(C)[C@@H](NC(=O)[C@@H](COP(=O)(OCC1=CN(C2=CC=CC=C21)C3=NC=NC=N3)O)N)C(=O)N[C@@H](C)C(=O)O
|
gptkbp:hasStorageCondition
|
Store below 30°C
|
gptkbp:hasUNII
|
53V6IL329L
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB15054
|
gptkbp:indication
|
gptkb:COVID-19
gptkb:Ebola_virus_disease_(investigational)
|
gptkbp:legalStatus
|
Prescription only
|
gptkbp:mechanismOfAction
|
RNA-dependent RNA polymerase inhibitor
|
gptkbp:metabolism
|
Hepatic
|
gptkbp:molecularWeight
|
602.6 g/mol
|
gptkbp:name
|
gptkb:Remdesivir
|
gptkbp:pregnancyCategory
|
Not assigned
|
gptkbp:PubChem_CID
|
121304016
CHEMBL2016761
D11472
|
gptkbp:routeOfAdministration
|
intravenous
|
gptkbp:sideEffect
|
nausea
elevated liver enzymes
hypersensitivity
|
gptkbp:status
|
FDA approved
EMA approved
|
gptkbp:synonym
|
gptkb:GS-5734
|
gptkbp:target
|
Ebola virus RNA polymerase
SARS-CoV-2 RNA polymerase
|
gptkbp:therapeuticArea
|
gptkb:disease
|
gptkbp:bfsParent
|
gptkb:Enhertu
|
gptkbp:bfsLayer
|
7
|